田小利

姓名：田小利

职务\职称：生命科学学院院长/教授

系别：流行病学与卫生统计学

研究方向：老年病机制及预防
工作邮箱：tianxiaoli@ncu.edu.cn

个人简介：

       武汉大学学士，北京协和医科大学硕士，柏林自由大学博士。科技部973首席。教授、博导。南昌大学生命科学学院院长，南昌大学人类衰老研究所所长，江西衰老重点实验室主任。

       中国生理学会衰老与健康专业委员会候任主委；中国老年学和老年医学学会（老年病学分会副会长，基础与转化医学分会副会长、衰老基础医学主任委员）；中国细胞生物学学会衰老细胞生物学学会副会长；中国生物物理学会衰老生物学分会副会长；中国老年学学会衰老与抗衰老科学委员会副主任委员；中国老年医学研究机构联盟副主任委员。编委：Aging Cell；BioEssays；Molecular Genetics and Genomics; Genes; Heart and Circulation

研究及成果：

       血管衰老及老年病的机制及干预。发表科研论文（包括Nature等期刊）87篇、书籍6部；获教育部科技进步奖2项，江西省科技进步奖1项、发明专利7 项

代表论文、专著与专利 （按倒序写，先写最近的相关内容，按照以下格式写：作者姓名。论文/专著/专利名称。发表期刊。发表时间，卷页码。两年内发表文章）

1. Changkun Long, Hongfei Liu, Wenxing Zhan, Liping Chen, Zhenping Yu, Shane Tian, Yang Xiang, Shenghan Chen, Xiao-Li Tian. Chronological attenuation of NPRA/PKG/AMPK signaling promotes vascular aging and elevates blood pressure. Aging Cell. 2022 Sep;21(9):e13699.  doi: 10.1111/acel.13699.  Epub 2022 Aug 25.

2. Shuangjin Ding, Jiankun Liu, XiaoRui Han, Wanqiu Ding, Zhirui Liu, Ying Zhu, Wenxing Zhan, Yiqi Wan, Shujie Gai, Junjie Hou, Xiaoxia Wang, Yixia Wu, Andong Wu, Chuan-Yun Li, Zhe Zheng, Xiao-Li Tian*, Huiqing Cao* ICAM-1-Related Noncoding RNA accelerates atherosclerosis by amplifying NF-κB signaling, JMCC, 2022(accepted)

3. Wan Y, Liu Z, Wu A, Khan AH, Zhu Y, Ding S, Li X, Zhao Y, Dai X, Zhou J, Liu J, Li Y, Gong X, Liu M, Tian XL*. Hyperglycemia Promotes Endothelial Cell Senescence through AQR/PLAU Signaling Axis. Int J Mol Sci. 2022 Mar 7;23(5):2879. doi: 10.3390/ijms23052879.

4. Zhang CF, Wang HM, Wu A, Li Y and Tian XL*. FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis. Science China Life sciences. 2021.

5. Sun ZC, Jiang Z, Xu X, Li M, Zeng Q, Zhu Y, Wang S, Li Y, Tian XL* and Hu C*. Fish Paralog Proteins RNASEK-a and -b Enhance Type I Interferon Secretion and Promote Apoptosis. Frontiers in immunology. 2021;12:762162.

6. Li Y, Yan H, Guo J, Han Y, Zhang C, Liu X, Du J and Tian XL*. Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease. Cardiovasc Res. 2021;117:240-255.

7. Li H, Wang X, Lu X, Zhu H, Li S, Duan S, Zhao X, Zhang F, Alterovitz G, Wang F, Li Q, Tian XL* and Xu M*. Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice. Aging (Albany NY). 2019;11:7620-7638.

8. Khan AH, Zou Z, Xiang Y, Chen S and Tian XL*. Conserved signaling pathways genetically associated with longevity across the species. Biochim Biophys Acta Mol Basis Dis. 2019;1865:1745-1755.

9. Zeng Y, Nie C, Min J, Chen H, Liu X, Ye R, Chen Z, Bai C, Xie E, Yin Z, Lv Y, Lu J, Li J, Ni T, Bolund L, Land KC, Yashin A, O'Rand AM, Sun L, Yang Z, Tao W, Gurinovich A, Franceschi C, Xie J, Gu J, Hou Y, Liu X, Xu X, Robine JM, Deelen J, Sebastiani P, Slagboom E, Perls T, Hauser E, Gottschalk W, Tan Q, Christensen K, Shi X, Lutz M, Tian XL*, Yang H and Vaupel J. Sex Differences in Genetic Associations With Longevity. JAMA Netw Open. 2018;1:e181670.

10. Song C, Yan H, Wang H, Zhang Y, Cao H, Wan Y, Kong L, Chen S, Xu H, Pan B, Zhang J, Fan G, Xin H, Liang Z, Jia W and Tian XL*. AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism. J Genet Genomics. 2018;45:111-120.

11. Li Y, Wang DW, Chen Y, Chen C, Guo J, Zhang S, Sun Z, Ding H, Yao Y, Zhou L, Xu K, Song C, Yang F, Zhao B, Yan H, Wang WJ, Wu C, Lu X, Yang X, Dong J, Zheng G, Tian S, Cui Y, Jin L, Liu G, Cui H, Wang S, Jiang F, Wang C, Erdmann J, Zeng L, Huang S, Zhong J, Ma Y, Chen W, Sun J, Lei W, Chen S, Rao S, Gu D, Schunkert H and Tian XL*. Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease. Arteriosclerosis, thrombosis, and vascular biology. 2018;38:964-975.

12. Ma JF, Yang F, Mahida SN, Zhao L, Chen X, Zhang ML, Sun Z, Yao Y, Zhang YX, Zheng GY, Dong J, Feng MJ, Zhang R, Sun J, Li S, Wang QS, Cao H, Benjamin EJ, Ellinor PT, Li YG and Tian XL*. TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians. Cardiovasc Res. 2016;109:442-50.

13. Li W, Zheng NZ, Yuan Q, Xu K, Yang F, Gu L, Zheng GY, Luo GJ, Fan C, Ji GJ, Zhang B, Cao H and Tian XL*. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. J Mol Med (Berl). 2016;94:993-1002.

14. Hu FY, Wu C, Li Y, Xu K, Wang WJ, Cao H and Tian XL*. AGGF1 is a novel anti-inflammatory factor associated with TNF-alpha-induced endothelial activation. Cell Signal. 2013;25:1645-53.

15. Zhao L, Yang F, Xu K, Cao H, Zheng GY, Zhang Y, Li J, Cui H, Chen X, Zhu Z, He H, Mo X, Kennedy BK, Suh Y, Zeng Y and Tian XL*. Common genetic variants of the beta2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging cell. 2012;11:1094-101.

16. Zeng Y, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, Xiao Z, Tan Q, Tian XL* and Vaupel JW. Effects of FOXO genotypes on longevity: a biodemographic analysis. The journals of gerontology. 2010;65:1285-99.

17. Li Y, Wang WJ, Cao H, Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, Li W, Zheng GY, Cui H, Chen X, Zhu Z, He H, Dong B, Mo X, Zeng Y and Tian XL*. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Human molecular genetics. 2009;18:4897-904.

18. Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q, Szafranski P, Rao S, Wu L, Housman DE, DiCorleto PE, Driscoll DJ, Borrow J and Wang Q. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature. 2004;427:640-5.

主持的科研项目

1) 2020.1-2024.12：项目负责人，国家科技部重点研发计划“营养、运动对老年健康的影响和干预作用”（2020YFC2002900，1700万）。

2) 2019.1-2022.12: 课题负责人，江西省重点研发计划--重点项目“冠心病相关基因的遗传筛查及个体化治疗评估体系的建立"（20192ACB70002，100万）。

3) 2018.1-2020.12：课题负责人，江西省科技厅重点项目“百岁老人逸脱冠心病的遗传机制”（20181ACB20017，50万）

4) 2018.1-2022.12：课题负责人，江西省“人类衰老重点实验室”主任（20181BCD40001，50万）

5) 2017.1-2022.12: 课题负责人，国家自然基金重点项目“个体衰老相关基因调节血管衰老的分子机制” （81630034，275万）

6) 2013.1-2017.8：首席，科技部973计划“血管衰老及相关疾病的生物学基础”（2013CB530700)

7) 2012.1-2016.12:课题负责人，国家自然基金重点项目“血管损伤早期应答和启动修复保护的信号转导机制以及通过AGGF1干预的可能性研究”（81130003）

8) 2011.1-2013.12：课题负责人，国家自然基金面上项目“血管新生因子AGGF1新异构体的功能鉴定”(81070262)

9) 2007-2011：课题负责人，科技部973项目分题（2007CB512103)“缺血性心脏病的分子遗传学基础”（973项目“重大心脏疾病分子机理和干预策略的基础研究”）

2007-2010：课题负责人，国家自然基金重点项目（30730047）“血管生成因子在血管发育畸形和瘤变中的分子调控机制”