曾令兵

姓名：曾令兵

职务\职称：主任技师

系别：临床检验诊断学

研究方向：临床微生物诊断

工作邮箱：lingbing_zeng@163.com

个人简介：

       毕业于上海交通大学（原上海第二医科大学），现任南昌大学第一附属医院主任技师、硕士生导师。长期从事临床微生物学检验工作，主持国家级省级课题多项，以第一作者和通讯作者署名发表学术论文二十余篇，副主编出版学术著作1部，荣获多种奖项和荣誉。

论文、专著与专利：

1.Zeng L, Huang Y, Tan J, Peng J, Hu N, Liu Q, Cao Y, Zhang Y, Chen J, Huang X. QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches. Front Cell Infect Microbiol. 2023 Feb 27;13:1136698. doi: 10.3389/fcimb.2023.1136698. PMID: 36923588; PMCID: PMC10009220.

2.Cai Q, Huang Y, Zhou L, Hu N, Liu Y, Guo F, Liu Q, Huang X, Zhang Y, Zeng L. A Complete Genome of Nocardia terpenica NC_YFY_NT001 and Pan-Genomic Analysis Based on Different Sources of Nocardia spp. Isolates Reveal Possibly Host-Related Virulence Factors. Infect Drug Resist. 2022 Dec 13;15:7259-7270. doi: 10.2147/IDR.S384673. PMID: 36536862; PMCID: PMC9758982.

3.Liu Y, Lin Y, Wang Z, Hu N, Liu Q, Zhou W, Li X, Hu L, Guo J, Huang X, Zeng L. Molecular Mechanisms of Colistin Resistance in Klebsiella pneumoniae in a Tertiary Care Teaching Hospital. Front Cell Infect Microbiol. 2021 Oct 26;11:673503. doi: 10.3389/fcimb.2021.673503. PMID: 34765565; PMCID: PMC8576191. （主要通讯作者）

4.Hu N, Wang D, Lin Y, Zou J, Liu Y, Xiong Z, Guo J, Zeng L, Li J. Molecular Analysis and Antimicrobial Resistance Pattern of Tigecycline-Non-Susceptible K. pneumoniae Isolated from a Tertiary Care Hospital of East Asia. Infect Drug Resist. 2021 Oct 7;14:4147-4155. doi: 10.2147/IDR.S334098. PMID: 34675559; PMCID: PMC8504710. （共同通讯）

5.Chen J, Hu N, Xu H, Liu Q, Yu X, Zhang Y, Huang Y, Tan J, Huang X, Zeng L. Molecular Epidemiology, Antifungal Susceptibility, and Virulence Evaluation of Candida Isolates Causing Invasive Infection in a Tertiary Care Teaching Hospital. Front Cell Infect Microbiol. 2021 Sep 15;11:721439. doi: 10.3389/fcimb.2021.721439. PMID: 34604110; PMCID: PMC8479822. （通讯作者）

6.Zhu J, Hu C, Zeng Z, Deng X, Zeng L, Xie S, Fang Y, Jin Y, Alezra V, Wan Y. Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism. Eur J Med Chem. 2021 Oct 5;221:113488. doi: 10.1016/j.ejmech.2021.113488. Epub 2021 May 1. PMID: 33991963.

7.Guo J, Zhang M, Qiao D, Shen H, Wang L, Wang D, Li L, Liu Y, Lu H, Wang C, Ding H, Zhou S, Zhou W, Wei Y, Zhang H, Xi W, Zheng Y, Wang Y, Tang R, Zeng L, Xu H, Wu W. Prevalence and Antifungal Susceptibility of Candida parapsilosis Species Complex in Eastern China: A 15-Year Retrospective Study by ECIFIG. Front Microbiol. 2021 Mar 4;12:644000. doi: 10.3389/fmicb.2021.644000. PMID: 33746933; PMCID: PMC7969513. （共同通讯）

8.Zhang H, Zeng L, Liu Q, Jin G, Zhang J, Li Z, Xu Y, Tian H, Deng S, Shi Q, Huang X. CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreatitis. PLoS Pathog. 2021 Feb 8;17(2):e1008992. doi: 10.1371/journal.ppat.1008992. PMID: 33556114; PMCID: PMC7895353. （共同第一）

9.Chen J, Liu Q, Zeng L, Huang X. Protein Acetylation/Deacetylation: A Potential Strategy for Fungal Infection Control. Front Microbiol. 2020 Oct 7;11:574736. doi: 10.3389/fmicb.2020.574736. PMID: 33133044; PMCID: PMC7579399.

10.Zhang Y, Hu N, Cai Q, Zhang F, Zou J, Liu Y, Wei D, Zhu Q, Chen K, Zeng L, Huang X. Treatment with the traditional Chinese medicine BuYang HuanWu Tang induces alterations that normalize the microbiome in ASD patients. Biosci Microbiota Food Health. 2020;39(3):109-116. doi: 10.12938/bmfh.2019-032. Epub 2020 Mar 6. PMID: 32775128; PMCID: PMC7392916.

11.Liu D, Zeng L, Yan Z, Jia J, Gao J, Wei Y. The mechanisms and safety of probiotics against toxigenic clostridium difficile. Expert Rev Anti Infect Ther. 2020 Oct;18(10):967-975. doi: 10.1080/14787210.2020.1778464. Epub 2020 Jun 16. PMID: 32520637.

12.Luo Q, Zeng L, Zeng L, Rao J, Zhang L, Guo Y, Huang Z, Li J. Expression and clinical significance of circular RNAs hsa_circ_0000175 and hsa_circ_0008410 in peripheral blood mononuclear cells from patients with rheumatoid arthritis. Int J Mol Med. 2020 Apr;45(4):1203-1212. doi: 10.3892/ijmm.2020.4498. Epub 2020 Feb 13. PMID: 32124964.

13.Zhang R, Zhou W, Ye Q, Song S, Wang Y, Xu Y, Zeng L. Comparative genomic analysis of Chinese human leptospirosis vaccine strain and circulating isolate. Hum Vaccin Immunother. 2020 Jun 2;16(6):1345-1353. doi: 10.1080/21645515.2020.1720439. Epub 2020 Feb 11. PMID: 32045318; PMCID: PMC7538020. （通讯作者）

14.Luo D, Chen Q, Xiong G, Peng Y, Liu T, Chen X, Zeng L, Chen K. Prevalence and molecular characterization of multidrug-resistant M. tuberculosis in Jiangxi province, China. Sci Rep. 2019 May 13;9(1):7315. doi: 10.1038/s41598-019-43547-2. PMID: 31086215; PMCID: PMC6513856.

15.He J, Zeng L, Wei R, Zhong G, Zhu Y, Xu T, Yang L. Lagopsis supina exerts its diuretic effect via inhibition of aquaporin-1, 2 and 3 expression in a rat model of traumatic blood stasis. J Ethnopharmacol. 2019 Mar 1;231:446-452. doi: 10.1016/j.jep.2018.10.034. Epub 2018 Oct 28. PMID: 30394291.

16.Chen X, Zeng L. Ginkgo biloba extract 761 enhances 5-fluorouracil chemosensitivity in colorectal cancer cells through regulation of high mobility group-box 3 expression. Am J Transl Res. 2018 Jun 15;10(6):1773-1783. PMID: 30018718; PMCID: PMC6038068. （通讯作者）

17.Chen K, Lin S, Li P, Song Q, Luo D, Liu T, Zeng L, Zhang W. Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern China. BMC Infect Dis. 2018 Jan 25;18(1):51. doi: 10.1186/s12879-018-2955-6. PMID: 29370771; PMCID: PMC5785813.

18.Zeng L, Wang D, Hu N, Zhu Q, Chen K, Dong K, Zhang Y, Yao Y, Guo X, Chang YF, Zhu Y. A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis. Front Microbiol. 2017 Mar 14;8:396. doi: 10.3389/fmicb.2017.00396. PMID: 28352257; PMCID: PMC5348505. （共同第一）

19.Chen K, Huang Y, Song Q, Wu C, Chen X, Zeng L. Drug-resistance dynamics of Staphylococcus aureus between 2008 and 2014 at a tertiary teaching hospital, Jiangxi Province, China. BMC Infect Dis. 2017 Jan 25;17(1):97. doi: 10.1186/s12879-016-2172-0. PMID: 28122513; PMCID: PMC5267434.

20.Zhang Y, Kong Y, Liu S, Zeng L, Wan L, Zhang Z. Curcumin induces apoptosis in human leukemic cell lines through an IFIT2-dependent pathway. Cancer Biol Ther. 2017 Jan 2;18(1):43-50. doi: 10.1080/15384047.2016.1276129. Epub 2017 Jan 10. PMID: 28071969; PMCID: PMC5323008.

21.Wang Y, Zhuang X, Zhong Y, Zhang C, Zhang Y, Zeng L, Zhu Y, He P, Dong K, Pal U, Guo X, Qin J. Distribution of Plasmids in Distinct Leptospira Pathogenic Species. PLoS Negl Trop Dis. 2015 Nov 10;9(11):e0004220. doi: 10.1371/journal.pntd.0004220. PMID: 26555137; PMCID: PMC4640553.

22.Zhou Y, Zhang Z, Wang H, Xia Y, Li X, Yan Y, Zou W, Zeng L, Huang X. In vitro interaction between coxsackievirus B3 VP1 protein and human pleckstrin homology domain retinal protein (PHR1). Virus Genes. 2015 Oct;51(2):182-9. doi: 10.1007/s11262-015-1241-6. Epub 2015 Aug 30. PMID: 26318175.

23.Zeng LB, Zhuang XR, Huang LL, Zhang YY, Chen CY, Dong K, Zhang Y, Cui ZL, Ding XL, Chang YF, Guo XK, Zhu YZ. Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants. J Proteomics. 2015 Jan 1;112:27-37. doi: 10.1016/j.jprot.2014.08.015. Epub 2014 Sep 6. PMID: 25201075. （共同第一）

主持的科研项目：

1.“问号钩体保守外分泌蛋白LA_0505的致病功能及机制研究”（81460300，国家自然基金），项目主持人，2018年12月已结题。

2.“问号钩体毒力相关AraC家族转录调控因子突变导致减毒的分子机制探究”（20192ACBL21042，江西省青年基金重点项目），项目主持人，在研。

3.“呼吸链复合体蛋白QCR2在白色念珠菌中的致病功能及机制研究”（20202BAB216045，江西省自然科学基金青年项目），项目主持人，在研。

4.“问号钩体丝氨酸蛋白酶致病功能及机制研究”（20204BCJL23054，江西省主要学术与学科带头人培养项目），项目主持人，在研。

“问号钩体保守Big结构域外分泌蛋白致病机制研究”（20151BAB205059，江西省自然基金一般项目），项目主持人，已结题。