李俊明

姓名：李俊明

职务\职称：教授、主任技师\检验科副主任

系别：临床检验诊断学

研究方向：抗感染免疫、自身免疫病、临床分子诊断

工作邮箱：lisir361@163.com

办公电话：0791-88692794; 13870878042

简介：毕业于重庆医科大学，获医学博士学位，现任南昌大学第一附属医院检验科副主任，教授、主任技师、博士生导师。入选江西省主要学科学术和技术带头人、江西省“双千计划”科技创新高端人才、江西省新世纪百千万人才工程培养对象，江西省青年科学家（井冈之星）培养对象，江西省卫生系统学术和技术带头人,江西省卫计委有突出贡献中青年专家，南昌大学215人才工程特聘教授等。

主要从事抗感染免疫、自身免疫病的发病机制及实验室诊断、临床分子诊断等研究。主持国家自然科学基金课题6项，省部级课题10余项，以第一作者和通讯作者发表专业论文80余篇，其中SCI收录40余篇。以第一成果人获得江西省科技进步二等奖、江西省自然科学三等奖和江西省高校科技成果一等奖各一项。

主要学术兼职包括：中华医学会检验分会青年委员，中华医学会微生物学与免疫学分会青年委员，中华医学会医学细胞生物学分会委员，中国医院协会临床微生物实验室管理专业委员会常务委员，中国防痨协会结核病转化医学专业委员会委员，江西省医学会检验分会常委，江西省医学会微生物学与免疫学分会候任主任委员,江西省免疫学会免疫检验分会副主任委员，江西省研究型医院学会检验分会副主任委员。担任《中华检验医学杂志》、《实验与检验医学》、《临床检验杂志》、《医学参考报》检验医学频道、《医学参考报》微生物与感染频道青年编委、编委或常务编委等职，是Cellular Physiology and biochemistry、Expert Opinion on Pharmacotherapy、Aging cell、Scientific Reports、AMB express、Plos One等期刊审稿人。

近5年发表的主要论文：

1.Huang Z, Liu J, Li L, Guo Y, Luo Q*, Li J*. Long non-coding RNA expression profiling of macrophage line RAW264.7 infected by Mycobacterium tuberculosis. Biotech Histochem. 2020 Aug;95(6):403-410.

2.Jiang M, Guo Y, Luo Q, Huang Z, Zhao R, Liu S, Le A*, Li J*, Wan L*. T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019. J Infect Dis. 2020 Jun 29;222(2):198-202.

3.Luo Q, Rao J, Zhang L, Fu B, Guo Y, Huang Z*, Li J*. The study of METTL14, ALKBH5, and YTHDF2 in peripheral blood mononuclear cells from systemic lupus erythematosus. Mol Genet Genomic Med. 2020 Jun 25:e1298.

4.Luo Q, Fu B, Zhang L, Guo Y, Huang Z*, Li J*. Decreased Peripheral Blood ALKBH5 Correlates with Markers of Autoimmune Response in Systemic Lupus Erythematosus. Dis Markers. 2020 :8193895.

5.Luo Q, Zhang L, Fang L, Fu B, Guo Y, Huang Z*, Li J*. Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus. Autoimmunity. 2020 Feb 24:1-10.

6.Luo Q, Liu J, Fu B, Zhang L, Guo Y, Huang Z*, Li J*. Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis. Dis Markers. 2019 Oct 29;2019:2073139.

7.Luo Q, Zhang L, Li X, Fu B, Guo Y, Huang Z*, Li J*. Identification of circular RNAs hsa_circ_0044235 and hsa_circ_0068367 as novel biomarkers for systemic lupus erythematosus. Int J Mol Med. 2019 Oct; 44(4):1462-1472.

8.Rigu Su, Yi-ping Peng, Zhen Deng, Ya-ting Deng, Jianq-ing Ye, Yang Guo, Zi-kun Huan1, Qing Luo, Hong Jiang, Jun-ming Li*. Mycobacterium tuberculosis Infection Induces Low-Density Granulocyte Generation by Promoting Neutrophil Extracellular Trap Formation via ROS Pathway. Front Microbiol. 2019, 10:1468.

9.Luo Q, Li X, Zhang L, Yao F, Deng Z, Qing C, Su R, Xu J, Guo Y, Huang Z, Li J*. Serum PGLYRP1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis. Mol Med Rep. 2019 Jan;19(1):589-594.

10.Luo Q, Li X, Fu B, Zhang L, Deng Z, Qing C, Su R, Xu J, Guo Y, Huang Z*, Li J*. Decreased expression of TIGIT in NK cells correlates negatively with disease activity in systemic lupus erythematosus. Int J Clin Exp Pathol. 2018 May 1;11(5):2408-2418.

11.Huang Z, Su R, Yao F, Peng Y, Luo Q*, Li J*. Circulating circular RNAs hsa_circ_0001204 and hsa_circ_0001747 act as diagnostic biomarkers for active tuberculosis detection. Int J Clin Exp Pathol. 2018 Feb 1;11(2):586-594.

12.Huang Z, Du J, Deng Z, Luo Q, Xiong G, Wang Y, Zhang X, Li J*. Multicentre laboratory validation of the nitrate reductase assay using liquid medium for the  rapid detection of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. Tuberculosis (Edinb). 2018 Dec;113:242-248.

13.Luo Q, Xiao P, Li X, Deng Z, Qing C, Su R, Xu J, Guo Y, Huang Z*, Li J*. Overexpression of CD64 on CD14(++)CD16(-) and CD14(++)CD16(+) monocytes of rheumatoid arthritis patients correlates with disease activity. Exp Ther Med. 2018 Sep;16(3):2703-2711.

14.Zikun Huang, Rigu Su, Cheng Qing, Yiping Peng, Qing Luo*, Junming Li*. Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis. Front. Microbiol. 2018, 9: 2010.

15.黄自坤,黄清水,罗清,姚芳苡,彭亦平,徐建青,张露,李俊明*. 血浆环状RNA hsa_circ_0009024表达在肺结核诊疗中的应用价值. 中华检验医学杂志, 2018, 41(5):399-404.

16.Huang ZK, Yao FY, Xu JQ, Deng Z, Su RG, Peng YP, Luo Q*, Li JM*. Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. Cell Physiol Biochem. 2018;45(3):1230-1240.

17.Luo Q, Li X, Xu C, Zeng L, Ye J, Guo Y, Huang Z*, Li J*. Integrative analysis of long non-coding RNAs and messenger RNA expression profiles in systemic lupus erythematosus. Mol Med Rep. 2018, 17(3): 3489-3496.

18.Luo Q, Ye J, Zeng L, Luo Z, Deng Z, Li X, Guo Y, Huang Z*, Li J*. Elevated expression of PD1 on T cells correlates with disease activity in rheumatoid arthritis. Mol Med Rep. 2018 Feb;17(2):3297-3305.

19.Luo Q, Xu C, Li X, Zeng L, Ye J, Guo Y, Huang Z*, Li J*. Comprehensive analysis of long non-coding RNA and mRNA expression profiles in rheumatoid arthritis. Exp Ther Med. 2017 Dec;14(6):5965-5973.

20.黄自坤,姚芳苡,赖松青,邓桢,徐建青,呙阳,罗清,李俊明*.长链非编码RNA肺腺癌转移相关转录本1对巨噬细胞极化影响的研究. 免疫学杂志,2017,33(12): 1021-1027.

21.Huang Z, Su R, Deng Z, Xu J, Peng Y, Luo Q*, Li J*. Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection. Sci Rep. 2017 Oct 20;7(1):13673.

22.Zikun Huang, Fangyi Yao, Zhen Deng, Suri Gu, Yiping Peng, Qing Luo*, Junming Li*. Elevated expression of Tim-3 in CD56dimCD16+ NK cells correlates with disease severity of pulmonary tuberculosis. Int J Clin Exp Pathol 2017;10(5):5031-5038.

23.Luo Q, Deng Z, Xu C, Zeng L, Ye J, Li X, Guo Y, Huang Z*, Li J*. Elevated Expression of Immunoreceptor Tyrosine-Based Inhibitory Motif (TIGIT) on T Lymphocytes is Correlated with Disease Activity in Rheumatoid Arthritis. Med Sci Monit. 2017; 23: 1232-1241.

24.Luo Q, Ye J, Zeng L, Li X, Fang L, Ju B, Huang Z*, Li J*. Elevated expression of TIGIT on CD3(+)CD4(+) T cells correlates with disease activity in systemic lupus erythematosus. Allergy Asthma Clin Immunol. 2017;13: 15.  

25.黄自坤, 姚芳苡, 罗清, 叶建青, 邓桢, 呙阳, 江红, 李俊明*. lincRNA-cox2 对小鼠RAW264.7 巨噬细胞极化的影响. 中华微生物学和免疫学杂志, 2016, 36(12): 881-886.

26.黄自坤，姚芳苡，邓亚婷，叶建青，罗清，熊国亮，李俊明*.肺结核患者外周血低密度粒细胞检测的临床意义. 免疫学杂志, 2017, 33(1): 40-45.

27.黄自坤, 姚芳苡, 罗清, 邓桢, 彭亦平, 呙阳, 李俊明*. 长链非编码RNA肺癌转移相关转录本1在结核感染中的表达及意义. 中华微生物学和免疫学杂志, 2016,36(11): 824-830.

28.Huang ZK, Luo Q, Qing C, Deng YT, Xiong GL, Li JM*. Evaluation of the direct nitrate reductase assay for rapid detection of extensively drug-resistant tuberculosis. Int J Tuberc Lung Dis. 2016, 20(4): 468-473.

29.Yating Deng, Jianqing Ye, Qing Luo, Zhikun Huang, Yiping Peng, Guoliang Xiong, Yang Guo, Hong Jiang, Junming Li*. Low-Density Granulocytes Are Elevated in Mycobacterial Infection and Associated with the Severity of Tuberculosis. PLoS One. 2016, 11(4): e0153567.

30.Qing Luo, Zikun Huang, Jianqing Ye, Yating Deng, Le Fang, Xue Li, Yang Guo, Hong Jiang, Beihua Ju, Qingshui Huang, and Junming Li*. PD-L1-expressing neutrophils as a novel indicator to assess disease activity and severity of systemic lupus erythematosus. Arthritis Res Ther. 2016, 18(1): 47.

31.Zikun Huang, Qing Luo, Fangyi Yao, Cheng Qing, Jianqing Ye, Yating Deng , Junming Li*. Identification of Differentially Expressed Long Non-coding RNAs in Polarized Macrophages. Scientific Reports, 2016, 6:19705.

32.Yang Guo, Yating Deng, Zikun Huang, Qing Luo, Yiping Peng, Jie Chen，Hong Jiang, Jianqing Ye, Junming Li*. EBP50 induces apoptosis in macrophages by upregulating nitric oxide production to eliminate intracellular Mycobacterium tuberculosis. Scientific Reports, 2016, 6, 18961.

33.Zikun Huang, Qing Luo, Yang Guo, Jie Chen, Guoliang Xiong, Yiping Peng, Jianqing Ye, Junming Li*. Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro. Plos One, 2015, 10(6): e0129744.

34.陈洁, 呙阳, 邓亚婷, 江红, 黄自坤, 罗清, 叶建青, 李俊明*. 慢病毒介导的 TACO-shRNA 通过促进吞噬体与溶酶体融合提高巨噬细胞清除结核分枝杆菌的能力.中华微生物学和免疫学杂志, 2015, 35(10): 735-740.

35.Huang Z, Qin C, Du J, Luo Q, Wang Y, Zhang W, Zhang X, Xiong G, Chen J, Xu X, Li W, Li J*. Evaluation of the microscopic observation drug susceptibility assay for the rapid detection of MDR-TB and XDR-TB in China: a prospective multicentre study. J Antimicrob Chemother. 2015;70(2):456-62.

主持的主要科研项目：

1、2020.01-2022.12. LDGs影响T-SPOT TB 检测的机制研究及T-SPOT TB优化检测方案的探索,江西省“双千计划”科技创新高端人才项目,200万

2、2018.01-2020.12.低密度粒细胞标志分子的筛选、鉴定及其在结核病相关LDN研究中的应用评价，江西省主要学科学术和技术带头人资助计划项目（20172BCB22026）, 50万

3、2018.01-2021.12.结核分枝杆菌调控PPAR-γ诱导泡沫巨噬细胞形成的机制及其在结核病免疫中的作用，国家自然科学基金项目 (81760002)，36万。

4、2017.07-2021.06.活性氧调控泡沫巨噬细胞形成的机制及其在结核病免疫中的作用研究，江西省自然科学基金重点项目 (20171ACB20032)，50万

5、2016.01-2019.12.基于PASS技术的egfr基因突变比例检测方法的建立及其在NSCLC患者靶向治疗预后评估中的应用研究，国家自然科学基金项目（81560344），37万

6、2015.05-2018.05. EGFR基因突变比例与非小细胞肺癌患者EGFR-TKI靶向治疗效果的相关性研究，江西省科技支撑计划项目（20151BBG70227），4万

7、2012.01-2015.12.巨噬细胞极化改变在结核性肉芽肿形成和发展中的作用及其调控机制研究，国家自然科学基金项目（81170006），60万

8、2011.01-2013.12.靶向自噬促进/结核分枝杆菌持留期抗原双相治疗性DNA疫苗研究, 国家自然科学基金项目（81060001）,25万

9、2010.01-2012.12. MODS在结核病快速诊断和药敏检测中的应用研究, 江西省科技支撑计划项目（2009BSB11219），1.5万

10、2010.01-2012.12.江西省青年科学家（井冈之星）培养对象计划项目：结核病治疗性疫苗研究（2009DQ01900），6万

11、2009.01-2011.12. LRG47/EBP50基因共修饰的耻垢分枝杆菌治疗性靶向载体疫苗的实验研究，国家自然科学基金项目 (30860256)， 25万

12、2007.01-2009.12.基因敲除减毒BCG靶向递送MФTACO特异性脱氧核酶表达载体治疗结核病的实验研究，国家自然科学基金课题 (30600528)， 21万