陈芳

姓名：陈芳

职务\职称：副教授

系别：营养与食品卫生学

研究方向：食品营养与健康，植物化学物的生物活性及其

作用机制

工作邮箱：xinganchenfang@163.com

简介：博士，毕业于南昌大学，现任南昌大学公共卫生学院副教授、硕士生导师。江西省优博，南昌大学赣江青年学者，江西省营养学会理事，中国环境诱变剂学会会员，江西省营养学会营养转化分会委员。曾于2011-2013年在中科院微生物研究所攻读联合培养硕士，于2015-2016年在美国University of Massachusetts攻读联合培养博士。近年来主持国家自然基金1项，江西省自然科学基金青年项目1项，医学部青年教师培育基金1项；参与企业横向课题2项，参与完成国家、省部级项目5项；在Journal of Agricultural and Food chemistry，food hydrocolloids，Journal of functional Foods，Food & function, Nutrients 等SCI杂志上发表论文30余篇；参编专著2部。

论文、专著与专利：

1)Qirui Hu, Xia Li, Fang Chen*, Renkou Wan, Cheng-wei Yu, Jing Li, David Julian McClements, and Zeyuan Deng*. Microencapsulation of an Essential Oil (Cinnamon Oil) by Spray Drying: Effects of Wall Materials and Storage Conditions on Microcapsule Properties. Journal of Food Processing and Preservation. 2020.(*共同通讯) (IF=1.405，四区)

2)Bin Peng, Fang Chen, Xianbiao Liu, Jiang-Ning Hu, Liu-Feng Zheng, Jing Li, Ze-Yuan Deng⁎. Trace water activity could improve the formation of 1,3-oleic-2-medium T chain-rich triacylglycerols by promoting acyl migration in the lipase RM IM catalyzed interesterification. Food Chemistry 313 (2020) 126130(IF=6.306，一区)

3)ShilianZheng, ZeyuanDeng, FangChen, LiufengZheng, Yao Pan, QianXing, RongTsao, HongyanLi. Synergistic antioxidant effects of petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: Role of Akt/Nrf2 pathway. JOURNAL OF FOOD SCIENCE. 2020, 85(6): 1752-1763.

4)Sheng-Ben Hu, QianZou, XinLv, Ruo-Lin Zhou, Xian Niu, Chen Weng, Fang Chen, Ya-Wei Fan, Ze-Yuan Deng, Jing Li*. 9t18:1 and 11t18:1 activate the MAPK pathway to regulate the expression of PLA2 and cause inflammation in HUVECs[J]. Food & Function, 2020, 11.

5)Fang Chen, Zipei Zhang, Zeyuan Deng, Ruojie Zhang, Guangqin Fan, Da Ma, David Julian McClements. Controlled-release of antacids from biopolymer microgels under simulated gastric conditions: Impact of bead dimensions, pore size, and alginate/pectin ratio. Food Research International, 2018, 106: 745–751. (IF=4.97，二区)

6)Fang Chen, Zeyuan Deng, Zipei Zhang, Ruojie Zhang, Qunying Xu, Guangqin Fan, David Julian McClements. Controlling lipid digestion profiles using mixtures of different types of microgel: alginate beads and carrageenan beads. Journal of food engineering. 2018, 238: 156-163. (IF=4.499，二区)

7)Li Jing, Hu Shengben, He Yueming, ZhuoChendfei, Zhou Ruolin, Chen Fang, Li Hongyan, Deng Zeyuan. 9c11tCLA modulates 11t18:1 and 9t18:1 induced inflammations differently in human umbilical vein endothelial cells[J]. Scientific Reports. 2018, 8(1).

8)Luo Ting, Lei Lin, Chen Fang, ZhengShilian, Deng Zeyuan. Iron homeostasis in the human body and nutritional iron deficiency and solutions in China. Journal of Food Biochemistry. 2018.

9)Sun Yong, HuiQianru, Chen Ran, Li Hongyan, Peng Han, Chen Fang, Deng Zeyuan. Apoptosis in human hepatoma HepG2 cells induced by the phenolics of Tetrastigmahemsleyanum leaves and their antitumor effects in H22 tumor-bearing mice[J]. Journal of Functional Foods, 2018, 40: 349-364.

10)Fang Chen, Guang-Qin Fan, Zipei Zhang, Ruojie Zhang, Ze-Yuan Deng*, David Julian McClements*, Encapsulation of omega-3 fatty acids in nanoemulsions and microgels: Impact of delivery system type and protein addition on gastrointestinal fate, Food Research International, 2017, 100: 387-395. (IF=4.97，二区)

11)Fang Chen, Yong Sun, Yan Qin, Shi-Lian Zheng, David Julian McClements, Jiang-Ning Hu*, Ze-Yuan Deng*. Antitumor and immunomodulatory effects of ginsenoside Rh2 and its octyl ester derivative in H22 tumor-bearing mice. Journal of functional foods. 2017, 32: 382-390. (IF=3.701，一区)

12)Fang Chen, Li Liang, Zipei Zhang, Zeyuan Deng*, Eric Andrew Decker, David Julian McClements*, Inhibition of lipid oxidation in nanoemulsions and filled microgels fortified with omega-3 fatty acids using casein as a natural antioxidant, Food Hydrocolloids. 2017, 63: 240-248. (IF=7.053，一区)

13)Yong Sun, RongTsao, Fang Chen, Hongyan Li, Jiawen Wang, Han Peng, Ke Zhang, Zeyuan Deng, The phytochemical composition, metabolites, bioavailability and in vivo antioxidant activity of Tetrastigmahemsleyanum leaves in rats. Journal of Functional Foods, 2017, 30: 179-193.

14)Sun Yong, TsaoRong, Chen Fang, Li Hongyan, Peng Han, Jiang Li, Chen Yuanhuan, Deng Zeyuan. The phenolic profiles of Radix Tetrastigma after solid phase extraction (SPE) and their antitumor effects and antioxidant activities in H22 tumor-bearing mice[J]. Food & Function, 2017, 8(11): 4014-4027.

15)Li Liang, Fang Chen, Xingguo Wang, Qingzhe Jin, Eric Andrew Decker, and David Julian McClements, Physical and Oxidative Stability of Flaxseed Oil-in-Water Emulsions Fabricated from Sunflower Lecithins: Impact of Blending Lecithins with Different Phospholipid Profiles. J. Agric. Food Chem. 2017, 65: 4755-4765.

16)BingjingZheng, Zipei Zhang, Fang Chen, Xiang Luo, David Julian McClements, Impact of delivery system type on curcumin stability: Comparison of curcumin degradation in aqueous solutions, emulsions, and hydrogel beads. Food Hydrocolloids. 2017, 71: 187-197.(影响因子5.089)

17)Zipei Zhang#, Fang Chen#, Ruojie Zhang, Zeyuan Deng, and David Julian McClements*, Encapsulation of pancreatic lipase in hydrogel beads with self-regulating internal pH microenvironments: Retention of lipase activity after exposure to gastric conditions, J. Agric. Food Chem. 2016, 64 (51), 9616-9623. (IF=4.192，一区)

18)Fang Chen, Ze-Yuan Deng, Bing Zhang, Zeng-Xing Xiong, Jiang-Ning Hu*, Esterification of ginsenoside Rh2 enhanced its cellular uptake and antitumor activity in human HepG2 cells, J. Agric. Food Chem. 2016. 64, 253-261. (IF=4.192，一区)

19)Fang Chen, Bing Zhang, Yong Sun, Zeng-Xing Xiong, Han Peng, Ze-Yuan Deng, Jiang-Ning Hu*, The octyl ester of ginsenoside Rh2 induces lysosomal membrane permeabilization via Bax translocation, Nutrients. 2016, 8(5): 244-258. (IF=4.546，二区)

20)Fang Chen, Shi-Lian Zheng, Jiang-Ning Hu*, Yong Sun, Yue-Ming He, Han Peng, Bing Zhang, David Julian McClements, and Ze-Yuan Deng*, Octyl Ester of Ginsenoside Rh2 Induces Apoptosis and G1 Cell Cycle Arrest in Human HepG2 Cells by Activating the Extrinsic Apoptotic Pathway and Modulating the Akt/p38 MAPK Signaling Pathway, J. Agric. Food Chem. 2016, 64 (40), 7520-7529. (IF=4.192，一区)

21)Hu, Jiang-Ning, Zou, Xian Guo, He, Yi, Chen, Fang, Deng, Ze Yuan. Esterification of Quercetin Increases Its Transport Across Human Caco-2 Cells [J]. Journal of food science, 2016, 81(7): 1825-1832.

22)杨建远, 陈芳, 宋沥文,等. 油茶籽油提取技术研究进展. 食品与机械, 2016(2):183-187.

23)Fang Chen, Ze-Yuan De, Zeng-Xing Xiong, Bing Zhang, Jian-Yuan Yang, Jiang-Ning Hu*, A ROS-mediated lysosomal-mitochondrial pathway is induced by ginsenoside Rh2 in hepatoma HepG2 cells, Food & function. 2015, 6, 3828-3837. (IF=4.171，一区)

24)Fang Chen, Yong Tao, Cheng Jin, Yang Xu, Bai-Xue Lin*, Enhanced production of polysialic acid by metabolic engineering of Escherichia coli,. Applied Microbiology and Biotechnology, 2015, 99: 2603-2611. (IF=3.53，二区)

25)许杨*, 陈芳, 林白雪, 陶勇. 全细胞催化生产N-乙酰神经氨酸的条件优化 [J]. 微生物学通报, 2013, 40(8): 1331-1338.

主持的科研项目：

1)201901-202212  基于CRT迁移研究Rh2-O诱导癌细胞的免疫原性死亡分子机制  国家自然科学地区基金（81860578）  35万元

2)201901-202112  人参皂苷Rh2及其辛酸酯衍生物对H22荷瘤小鼠的免疫调节作用及其分子机制  南昌大学医学部青年教师科研培育基金（PY2018）5万元

201801-202012  基于TLR4 /NF-κB信号通路研究人参皂苷Rh2及其辛酸酯衍生物对H22荷瘤小鼠的免疫调节作用及其分子机制  江西省自然科学基金青年项目（20181BAB215034）  6万元