刘洋

姓名：刘洋

职务\职称：科副主任、主管技师

系别：医学检验系

研究方向：感染致病机制，耐药及快速诊断

工作邮箱：344803452@qq.com

简介：2008年毕业于南昌大学公共卫生学院医学检验获学士学位，2011年获温州医科大学临床检验诊断学硕士学位；2019年获得南昌大学临床医学博士学位。现任南昌大学第一附属医院检验科副主任、硕士生导师，江西省整合医学会临床药师学会常委，江西省整合医学会全科分会常委，江西省医学检验分会青年委员，江西省整合医学会检验分会委员，南昌大学第一附属医院抗菌药物合理使用管理小组成员等。长期从事临床微生物检验的教学和科研工作，主持国家级省级课题多项，公开发表论文50余篇，其中SCI论文20余篇，副主编微生物检验教材1部，参与编写微生物检验专著1部，以第一完成人荣获江西省科技进步三等奖一项，江西省科技进步二等奖一项。

论文、专著与专利：

1.Liu Yang, Yan LM, Wan L, Xiang TX, Le A, Liu JM, Peiris M, Poon LLM, Zhang W. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020 Jun;20(6):656-657.

2.Liu Yang, Liao W, Wan L, Xiang T, Zhang W. Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. Viral Immunol. 2020 Apr 10. doi: 10.1089/vim.2020.0062.

3.Liao W, Wang L, Li D, Du FL, Long D,Liu Yang（通讯作者）, Ng O, Zhang W. High Prevalence of 16s rRNA Methylase Genes Among Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Isolates in a Chinese Tertiary Hospital. Microb Drug Resist. 2020 May 19. doi: 10.1089/mdr.2019.0482.

4.Liao W, Liu Yang（共同第一作者）, Chen C, Li J, Du F, Long D, Zhang W. Distribution of CRISPR-Cas Systems in Clinical Carbapenem-Resistant Klebsiella pneumoniae Strains in a Chinese Tertiary Hospital and Its Potential Relationship with Virulence. Microb Drug Resist. 2020 Jun;26(6):630-636.

5.Liao W, Long D, Huang Q, Wei D, Liu X, Wan L, Feng Y, Zhang W, Liu Yang（通讯作者）. Rapid Detection to Differentiate Hypervirulent Klebsiella pneumoniae (hvKp) From Classical K. pneumoniae by Identifying peg-344 With Loop-Mediated Isothermal Amplication (LAMP). Front Microbiol. 2020 Jun 4;11:1189. doi: 10.3389/fmicb.2020.01189.

6.Wei DD, Xiong XS, Mei YF, Du FL, Wan LG, Liu Yang（通讯作者）. Microbiological and Clinical Characteristics of Klebsiella pneumoniae Isolates of K57 Capsular Serotype in China. Microb Drug Resist. 2020 Aug 7. doi: 10.1089/mdr.2018.0456.

7.Li Dan, Liao Wenjian, Liu Yang（共同通讯作者） et al. Klebsiella pneumoniaeEmergence of Hypervirulent Ceftazidime/Avibactam-Resistant  Isolates in a Chinese Tertiary Hospital.[J] ., 2020, 13: 2673-2680.

8.Liao Wenjian, Liu Yang（共同通讯作者）,Zhang Wei,Virulence evolution, molecular mechanisms and prevalence of ST11 Carbapenem-resistant Klebsiella pneumoniae in China: A review over ten last years.J Glob Antimicrob Resist. 2020 Sep 21:S2213-7165(20)30235-6.

9.Li Xiaolei, Liu Yang（共同第一作者）, Li Junming et al. Immune characteristics distinguish patients with severe disease associated with SARS-CoV-2. Immunol Res. 2020 Sep 28:1–7.

10.Liu Y, Liu PP, Wang LH, Wei DD, Wan LG*, Zhang W. Capsular Polysaccharide Types and Virulence-Related Traits of Epidemic KPC-Producing Klebsiella pneumoniae Isolates in a Chinese UniversityHospital. Microb Drug Resist. 2017 Oct;23(7):901-907.

11.Liu Yang, Dan long, Tian-xin Xiang, Fang-Lin Du, Dan Dan Wei, La-Gen Wan, Qiong Deng, Xian-Wei Cao, Wei Zhang. Whole genome assembly and functional portrait of hypervirulent extensively drug-resistant NDM-1 and KPC-2 co-producing Klebsiella pneumoniae of capsular serotype K2 and ST86. Journal of Antimicrobial Chemotherapy. 2019, 74: 1233-1240.

12.Du F, Wei DD, Wan LG, Cao XW, Zhang W, Liu Y（通讯作者）. Evaluation of ompK36 allele groups on clinical characteristics and virulence features of Klebsiella pneumoniae from bacteremia. J Microbiol Immunol Infect. 2018 Oct 9. pii: S1684-1182(18)30422-5.

13.Liu Y, Du FL, Xiang TX, Wan LG, Wei DD, Cao XW, Zhang W*. High Prevalence of Plasmid-Mediated Quinolone Resistance Determinants Among Serotype K1 Hypervirulent Klebsiella pneumoniae Isolates in China. Microb Drug Resist. 2019 Jan 7.

14.Mei YF, Liu P-P, Wan L-G, Liu Y（通讯作者）, Wang L-h, Wei D-D, Deng Q and Cao X-W. Virulence and Genomic Feature of a Virulent Klebsiella pneumoniae Sequence Type 14 Strain of Serotype K2 Harboring blaNDM-5 in China. Front. Microbiol. 2017, 8:335.

主持的科研项目：

1.2020.01-2020.12《pLVPK-like毒力质粒在高毒力肺炎克雷伯菌中的接合转移分子机制研究》国家自然科学基金优青培育项目（20202ZDB01016），25万

2.2017.1-2020.12《高毒力肺炎克雷伯菌blaKPC基因捕获的分子机制及其环境适应度研究》，江西省自然科学基金(20161BAB205247），7万

3.2017.01-2019.12《非编码smallRNA作为高毒力肺炎克雷伯菌诊断新分子标志物的筛选与鉴定》，江西省重点研发项目（20171BBG70053），20万

4.2019.01-2022.12《临床菌株的耐药特征研究及抗菌药物体外活性验证》，国家重大专项项目（2019ZX09721001-006-004），75万

5.2016.1-2020.12，《肺炎克雷伯菌高毒力株分泌蛋白Hcp1调控PMN凋亡机制及其在脓毒症继发迁徙性感染中的作用》国家自然科学基金地区项目（81560323），37万

6.2018.1-2020.12《基于宏基因组学技术探讨气温降低诱发AECOPD的肺部微生态学改变及干预机制研究》，江西省自然科学基金(20181BAB205002），6万

7.2015.1-2017.12《分泌蛋白Hcp1在高毒力肺炎克雷伯菌新型变种的特异性表达及在其致病性与迁徙性播散中的机制》，江西省自然科学基金(20151BAB215028），5万