王槐

姓名：王槐

职务\职称：讲师

系别：职业与环境健康系

研究方向：肿瘤毒理及其化学预防

工作邮箱：wonghuai@hotmail.com

简介：毕业于武汉大学，博士。现任南昌大学公共卫生学院讲师、硕士生导师，中国环境诱变剂学会会员、中国环境诱变剂学会第六届致癌专业委员会委员、中国毒理学会会员。从事职业卫生与职业医学教研工作。入职以来，以第一作者或通讯作者发表科学研究论文11篇。主持课题多项。指导学生完成2项国家级大学生创新创业项目，荣获南昌大学校级教学成果奖二等奖1项（第一完成人），以第一作者发表核心期刊教学研究论文1篇。

论文、专著与专利：

(1) Huai Wang, Junjie Zhao, Jian Yang, Shukun Wan, Yihong Fu, Xinlu Wang, Tong Zhou, Zhongwei Zhang, Jiaomei Shen*. PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by microtubule polymerization inhibitor against cervical cancer. BBA - Molecular Cell Research, 2021, 1868(10): 119084.

(2) Huai Wang*, Lu Chen, Tong Zhou, Zhongwei Zhang, Canwei Zeng. p53 mutation at Serine 249 and its gain of function are highly related to hepatocellular carcinoma after smoking exposure. Public Health Genomics, 2021, DOI: 10.1159/000516598.

(3) Huai Wang*, Lu Chen, Tong Zhou, Zhongwei Zhang, Canwei Zeng. Nicotine promotes WRL68 cells proliferation due to the mutant p53 gain-of-function by activating CDK6-p53-RS-PIN1-STAT1 signaling pathway. Chemical Research in Toxicology, 2020, 33(9): 2361-2373.

(4) Huan Chen, Mingyang Zhang, Ziping Wang, Lingqi Li, Qiqi Li, Huai Wang*. The effect of p53-R249S on the suppression of hepatocellular carcinoma cells survival induced by podophyllum derivatives. Anti-Cancer Agents in Medicinal Chemistry, 2020, 20(7): 865-874.

(5) Huai Wang, Peng Liao, Shelya X. Zeng, Hua Lu*. Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells. Cancer Biology & Therapy, 2020, 21(3): 269-277.

(6) Lu Chen, Huai Wang*. eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology, 2019, 419(1): 1-10.

(7) Huai Wang, Peng Liao, Shelya X. Zeng, Hua Lu*. It takes a team: A gain-of-function story of p53-R249S. Journal of Molecular Cell Biology, 2019, 11(4): 277-283.

(8) Lu Chen, Huai Wang*. Nicotine promotes human papillomavirus (HPV)-immortalized cervical epithelial cells (H8) proliferation by activating RPS27a-Mdm2-P53 pathway in vitro. Toxicological Sciences, 2019, 167(2): 408-418.

(9) Huai Wang*, Jiang Feng, Tong Zhou, Lijun Wei, Jianmin Zhou. Involvement of RPL11 in the enhancement of P53 stability by a podophyllum derivative, a topoisomerase II inhibitor. Cell Biology International, 2018, 42(1): 121-129.

(10) Huai Wang*, Jiang Feng, Tong Zhou, Lijun Wei, Jianmin Zhou. P-3F, a microtubule polymerization inhibitor enhances P53 stability through the change in localization of RPS27a. International Journal of Biochemistry & Cell Biology, 2017, 92(12): 53-62.

(11) Huai Wang*. Podophyllum derivatives containing fluorine atom in the 3-position of 2-aminopyridine improved the antitumor activity by inducing P53-dependent apoptosis. Medicinal Chemistry Research, 2017, 26(6): 1279-1290.

(12) 王槐*, 况杰, 周彤, 冯江, 危丽俊, 周建明. 翻转课堂联合PBL在卫生化学实验教学中的应用研究[J].中华医学教育探索杂志, 2019, 18(7): 700-705.

主持的科研项目：

(1) 2018.10-2021.09，江西省自然科学基金面上项目（20181BAB205089），“PICT1介导DNA损伤类化合物增强P53蛋白稳定性的分子调控机制”， 6万

(2) 2017.07-2020.06, 江西省自然科学基金青年项目（20171BAB215076），“PICT1介导微管解聚类化合物诱导癌细胞中p53蛋白表达的分子调控机制”， 6万

(3) 2017.01-2019.12，江西省卫生计生委科技计划项目（20175530），“去甲表鬼臼毒素衍生物上调p53蛋白表达的调控机制系统研究”，0.5万

(4) 2016.01-2018.12，江西省教育厅科学技术研究项目（GJJ150109），“2-NH2吡啶3位取代的氮连接修饰鬼臼毒素类衍生物构效关系研究”，2万