邓立彬

姓名：邓立彬

职务/职称：教授

系别：流行病学与卫生统计学

研究方向：分子流行病

工作邮箱：denglb1937@163.com

个人简介：

       2001年毕业于同济医科大学公共卫生学院获学士学位，2007年毕业于中国科学院获博士学位，现任南昌大学公共卫生学院教授；获评“江西省高校第七批中青年骨干教师”、“江西省青年科学家培养对象”、中国遗传学会法医遗传学会分会委员、江西省医学遗传学分会常务委员、江西省医学会大数据与人工智能分会常务委员、江西省细胞生物学学会理事、江西省神经生物学会理事。主持国家级省级部级课题多项，以第一作者和通讯作者署名发表SCI论文20余篇。参编出版教材多部，荣获省级教学成果奖2项；指导本科生获得“互联网+”大学生创新创业大赛国家级金奖2项、省级铜奖1项。

论文、专著与专利（按倒序写，先写最近的相关内容，按照以下格式写：作者姓名。论文/专著/专利名称。发表期刊。发表时间，卷页码。）

1. Duan S*, Gao J*, Lou W, Zhang Y, Deng Y, Wang C, Huang H, Xu H , Guo S, Lai S, Xi F , Li Z, Deng L#, Zhong Y#. (2022). Prognostic signature for hepatocellular carcinoma based on 4 pyroptosis-related genes. BMC Med Genomics. 15(1):166.

2. Deng L*, Xu J*, Chen W, Guo S, Steiner R, Chen Q, Cheng Z, Xu Y, Yao Y, Li X, Wang X, Deng K, Schrodi S, Zhang D#, Xin H#. (2021). Remediation of ABCG5-Linked Macrothrombocytopenia With Ezetimibe Therapy. Front Genet. 12:769699.

3. Liu Z*, Wu H*, Deng J*, Wang H, Wang Z, Yang A, Liang B, Luo J, Li J, Xu Y, Tang X, Fu F#, Deng L#. (2020). Molecular classification and immunologic characteristics of immunoreactive high-grade serous ovarian cancer. J Cell Mol Med. 24: 8103~8114.

4. Xu Y, Li J, Yang W, Tang X, Huang B, Liu J, Lin J, Zhang J, Yang W, Li S, Sun F, Deng L#, Wang X#. (2020). A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population. Int J Genomics.2020:7531876.

5. Chen S*, Liu M*, Liang B*, Ge S, Peng J, Huang H, Xu Y, Tang X, Deng L#. (2020). Identification of human peripheral blood monocyte gene markers for early screening of solid tumors. PLoS One. 15(3):e0230905.

6. Sima X, He J, Peng J, Xu Y, Zhang F, Deng L#. (2019). The genetic alteration spectrum of the SWI/SNF complex: The oncogenic roles of BRD9 and ACTL6A. PLoS One. 14(9): e0222305.

7. Cheng Z, Wen Y, Liang B, Chen S, Liu Y, Wang Z, Cheng J, Tang X, Xin H, Deng L#. (2019). Gene expression profile-based drug screen identifies SAHA as a novel treatment for NAFLD. Molecular Omics, 15(1): 50~58.

8. Shi C*, Xu H*, Liu J, Zhong Y, Zhang X, Tong X, Zhang L, Li X, Deng L#. (2019). Alternatively activated NUSAP1 promotes tumor growth and indicates poor prognosis in hepatocellular carcinoma. Transl Cancer Res, 8(1): 238~247.

9. Deng L*, Huo L*, Zhang J, Tang X, Cheng Z, Li G, Fang X, Xu J, Zhang X, Xu R. (2017). Polymorphism of rs3737597 in DISC1 Gene on Chromosome 1q42.2 in sALS Patients: a Chinese Han Population. Mol Neurobiol, 54(5):3162~3180.

10. Deng L, Zhang C, Miao D, Tang X, Luo S, Xin HB, Shi H. (2017). Mediator complex components are frequent targets for genetic alteration in various types of human cancer. J. Genet. Genomics, 44(12):587-591.

11. Hu Y*, Deng L*, Zhang J*, Fang X, Mei P, Cao X, Lin J, Wei Y, Zhang X, Xu R. (2016). A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson's Disease in the Han Population of Chinese Mainland. Mol Neurobiol, 53(7):4302-18.

12. Tang X*, Deng L*, Xiong H*, Li G*, Lin J, Liu S, Xie J, Liu J, Kong F, Tu G, Peng H, Liang S*. (2014). Expression Profiles of Skeletal Muscle and Liver Implicate MAPK Signaling Pathways in Diabetes Pathology. INDIAN J MED RES, 140(6):744-755.

13. Xie T*, Deng L*, Mei P, Zhou Y, Wang B, Zhang J, Lin J, Wei Y, Zhang X*, Xu R*. (2014). A genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. Neurobiol Aging, 35(7):1778.e9-1778.e23.

14. Gao Y*, Liu H*, Deng L*, Zhu G*, Xu C, Li G, Liu S, Xie J, Liu J, Kong F, Wu R, Li G, Liang S. (2011). Effect of emodin on neuropathic pain transmission mediated by P2X(2/3) receptor of primary sensory neurons. Brain Res Bull, 84(6):406-13.

15. Beall C, Cavalleri G, Deng L, Elston R, Gao Y, Knight J, Li C, Li J, Liang Y, McCormack M, Montgomery H, Pan H, Robbins P, Shianna K, Tam S, Tsering N, Veeramah K, Wang W, Wangdui P, Weale M, Xu Y, Xu Z, Yang L, Zaman M, Zeng C, Zhang L, Zhang X, Zhaxi P, Zheng Y. (2010). Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders. PNAS ,107(25): 11459-11464.

16. Deng L, Zhang D, Richards E, Tang X, Long F, Fang J, Wang Y. (2009) Constructing an initial map of transmission distortion based on high density HapMap SNPs across the human autosomes. J. Genet. Genomics, 36(12): 703-709.

17. Deng L, Zhang Y, Kang J, Liu T, Zhao H, Gao Y, Li C, Pan H, Tang X, Wang D, Niu T, Yang H, Zeng C. (2008). An Unusual Haplotype Structure on Human Chromosome 8p23 Derived from the Inversion Polymorphism. Hum Mutat, 29(10): 1209-1216.

18. Deng L, Tang X, Kang J, Wang Q and Zeng C. (2007). Scanning for signatures of geographically restricted selection based on population genomics analysis. Chinese Sci. Bull, 52(19): 2649-2656.   (中文版：邓立彬，汤晓丽，康健，王青芸，曾长青；（2007）； 利用群体基因组学策略扫描人群特异的自然选择信号；科学通报，52(18)：2127-2133)

19. Tang X*, Deng L*, Zhang D, Lin J, Wei Y, Zhou Q, Li X, Li G, Liang S. (2012). Gene2DGE: a Perl package for gene model renewal with digital gene expression data. Genomics Proteomics Bioinformatics, 10(1):51-4.

20. Luo C*, Deng L*, and Zeng C. (2004). High throughput SNP genotyping with two mini-sequencing assays. Acta Biochim. Biophys. Sin, 36: 379-384.

21. Luo C*, Deng L*, Zhou J, Lin W and Zeng C. (2004). High throughput SNP genotyping with FP-TDI. Prog. Biochem. Biophys, 31(8): 731-735.

22. Deng L, Tang X, Hao X, Chen W, Yu Y, Zhang D, Zeng C. (2011). Genetic Flux Between H1 and H2 Haplotypes of the 17q21.31 Inversion in European Population. Genomics. Proteomics & Bioinformatics, 9(3): 113-118.

23. Deng L, Tang X, Chen W, Lin J, Lai Z, Liu Z, Zhang D. (2010). Scanning for Genomic Regions Subject to Selective Sweeps Using SNP-MaP Strategy. Genomics Proteomics Bioinformatics, 8(4): 256-261.

专利及著作权:

1. 一种卵巢癌分子分型预测系统. 邓立彬,王豪庆,梁博文,王紫璇,杨霭琳,傅芬,汤晓丽. 中国ZL 2018 1 1389851.4. 2021/9/24 (发明专利)

2. 一种基于卷积神经网络的牙周炎智能检测方法及系统. 邓立彬,宋莉,葛尚华,刘强冬,戴芳,娄伟明,李璨,杨晶晶,陈霖佳,彭捷,田菊,吴婧婷,邹源,俞晴.中国ZL 2020 1 0966941.6 2022/8/30 (发明专利)

3. 基于CNN的牙周炎分期分级系统V1.0. 邓立彬；宋莉；戴芳；葛尚华；南昌大学第二附属医院. 2021SR0915429. 2021/6/18 (著作权)

4. 一种基于心电图像的帕金森预测智能化方法及系统. 邓立彬,范广勤,冯昶,王钰婷,娄伟明,张伊楚,谢锐翔,黄卫. CN202111580521.5. 2021/12/22 (发明专利)

5. 一种基于病理图像的卵巢癌患者化疗敏感性的预测方法及系统. 邓立彬,娄伟明,汤晓丽,刘越,葛尚华,邬以国,高建莹,傅芬,石超. CN202111487778.6. 2021/12/7 (发明专利)

主持的科研项目

1. 2021.1-2024.12：国家自然科学基金地区项目“PTMA通过改变肝细胞组蛋白修饰促进NAFLD的作用机制”（82060112）

2. 2017.1-2020.12：国家自然科学基金地区项目“PPARA相关rSNP的组学筛查及其在高胆固醇血症中的协同致病机制”（81660041）

3. 2013.1-2016.12：国家自然科学基金地区项目“家族性高胆固醇血症相关功能突变的组学筛查及基因敲除小鼠模型的建立”（81260021）

4. 2009.1-2011.12：国家自然科学基金面上项目“正选择在人群分化及中国人特异遗传背景形成中作用的研究”（30871384）

5. 2018.01-2020.12：江西省自然科学基金面上项目“rSNP在PPAR信号通路紊乱致高胆固醇血症中的机制探讨”（20181BAB205008）

6. 2012.01-2014.12：江西省自然科学基金青年项目“肝脏免疫相关通路在大鼠高糖高脂耐受机制中的作用”（20114BAB215019）

7. 2013.01-2015.12：江西省教育厅面上项目“汉族人体质表型特征关联的遗传标记发现和功能推断（GJJ13091）

8. 2010.01-2011.12：江西省教育厅面上项目“江西人群老年痴呆候选基因多态性普查及风险预测”（GJJ10303）

2017.11-.2019.11：江西省研究生教育创新计划项目“大数据背景下医学研究生《生物信息学》创新教学的探索和实践”（JXYJG-2017-016）