陈芳

姓名：陈芳

职务/职称：副教授

系别：营养与食品卫生学

研究方向：食品营养与健康，植物化学物的生物活性及其作用机制

工作邮箱：xinganchenfang@163.com

个人简介：

       毕业于南昌大学，现任南昌大学公共卫生学院副教授、硕士生导师，江西省主要学科学术和技术带头人（青年人才项目），江西省优博，赣江青年学者，中国营养学会营养转化医学分会委员，中国毒理学会表观遗传学毒理专业委员会委员，江西省营养学会理事，江西省营养学会营养转化分会委员，第一届《食品研究与开发》青年委员，Phytomedicine、Journal of Agricultural and Food Chemistry等杂志审稿人。为中科院微生物研究所联合培养硕士和美国University of Massachusetts联合培养博士。近5年主持国家自然科学基金1项，江西省自然科学基金3项，南昌大学医学部青年教师培育项目1项，主持、参与企业横向课题3项，在Food Hydrocolloids，J. Agric. Food Chem.，Nutrients等期刊上发表SCI论文30余篇。主编/参编教材、专著5部，获得南昌大学青年教师授课比赛三等奖，为本科生开设营养与食品卫生学，健康教育学，临床营养学等6门课程。

论文：

1) 戴珍珍, 黄青昕, 胡淇睿, 吴汉城, 潘瑶, 邓泽元, 陈芳. 人参皂苷辛酸酯通过内质网应激诱导肝癌细胞免疫原性细胞死亡的机制研究[J/OL]．中国免疫学杂志. https://kns.cnki.net/kcms/detail//22.1126.R.20221228.1510.001.html.（2022-12-29）

2) Qi-rui Hu, Yao Pan, Han-cheng Wu, Zhen-zhen Dai, Qing-xin Huang, Ting Luo, Jing Li, Ze-yuan Deng, Fang Chen*. The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo. Journal of Ginseng Research. 2023,47(2): 173-182 .

3) Qi-rui Hu, Peng-wei Lai, Fang Chen*, Yan-fang Yu, Bing Zhang, Hongyan Li, Rong Liu, Yawei Fan, Ze-yuan Deng*. Whole mulberry leaves as a promising functional food: From the alteration of phenolic compounds during spray drying and in vitro digestion[J]. Journal of Food Science. 2022, 87(3): 1230-1243.

4) Li, X. ,  Wei, T. ,  Wu, M. ,  Chen, F. ,  Zhang, P. , &  Deng, Z. Y. , et al. Potential metabolic activities of raspberry ketone. Journal of Food Biochemistry. 2022, 46(1): e14018.

5) Han-cheng Wu, Qi-rui Hu, Ting Luo, Wen-cheng Wei, Hui-juan Wu, Jing Li, Liu-feng Zheng, Qun-ying Xu, Ze-yuan Deng*, Fang Chen*. The immunomodulatory effects of ginsenoside derivative Rh2-O on splenic lymphocytes in H22 tumor-bearing mice is partially mediated by TLR4. International Immunopharmacology. 2021, 101(ptB):108316. DOI: 10.1016/j.intimp.2021.108316

6) Qirui Hu, Xia Li, Fang Chen*, Renkou Wan, Cheng-wei Yu, Jing Li, David JulianMcClements, and Zeyuan Deng*. Microencapsulation of an Essential Oil (Cinnamon Oil) by Spray Drying: Effects of Wall Materials and Storage Conditions on Microcapsule Properties. Journal of Food Processing and Preservation. 2020, 44（11）.

7) Shilian Zheng, ZeyuanDeng, FangChen, LiufengZheng, Yao Pan, QianXing, RongTsao, HongyanLi. Synergistic antioxidant effects of petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: Role of Akt/Nrf2 pathway. JOURNAL OF FOOD SCIENCE. 2020, 85(6): 1752-1763.

8) Sheng-Ben Hu, QianZou, XinLv, Ruo-Lin Zhou, Xian Niu, Chen Weng, Fang Chen, Ya-Wei Fan, Ze-Yuan Deng, Jing Li*. 9t18:1 and 11t18:1 activate the MAPK pathway to regulate the expression of PLA2 and cause inflammation in HUVECs[J]. Food & Function, 2020, 11.

9) Bin Peng, Fang Chen, Xianbiao Liu, Jiang-Ning Hu, Liu-FengZheng, Jing Li, Ze-Yuan Deng⁎. Trace water activity could improve the formation of 1,3-oleic-2-medium T chain-rich triacylglycerols by promoting acyl migration in the lipase RM IM catalyzed interesterification. Food Chemistry 313 (2020) 126130.

10) Fang Chen, Zipei Zhang, Zeyuan Deng, Ruojie Zhang, Guangqin Fan, Da Ma, David Julian McClements*. Controlled-release of antacids from biopolymer microgels under simulated gastric conditions: Impact of bead dimensions, pore size, and alginate/pectin ratio. Food Research International,2018, 106: 745–751.

11) Fang Chen, Zeyuan Deng, Zipei Zhang, Ruojie Zhang, QunyingXu, Guangqin Fan, David Julian McClements. Controlling lipid digestion profiles using mixtures of different types of microgel: alginate beads and carrageenan beads. Journal of food engineering. 2018, 238: 156-163.

12) Fang Chen, Yong Sun, Yan Qin, Shi-LianZheng, David Julian McClements, Jiang-Ning Hu*, Ze-Yuan Deng*. Antitumor and immunomodulatory effects of ginsenoside Rh2 and its octyl ester derivative in H22 tumor-bearing mice.Journal of functional foods.2017, 32:382-390.

13) Fang Chen, Li Liang, Zipei Zhang, Zeyuan Deng*, Eric Andrew Decker, David Julian McClements*, Inhibition of lipid oxidation in nanoemulsions and filled microgels fortified with omega-3 fatty acids using casein as a natural antioxidant,Food Hydrocolloids.2017, 63: 240-248.

14) Fang Chen, Guang-Qin Fan, Zipei Zhang, Ruojie Zhang, Ze-Yuan Deng*, David Julian McClements*, Encapsulation of omega-3 fatty acids in nanoemulsions and microgels: Impact of delivery system type and protein addition on gastrointestinal fate, Food Research International, 2017, 100: 387-395.

15) Zipei Zhang#, Fang Chen#, Ruojie Zhang, Zeyuan Deng, and David Julian McClements*, Encapsulation of pancreatic lipase in hydrogel beads with self-regulating internal pH microenvironments: Retention of lipase activity after exposure to gastric conditions, J. Agric. Food Chem.2016, 64 (51), 9616-9623.

16) Fang Chen, Bing Zhang, Yong Sun, Zeng-Xing Xiong, Han Peng, Ze-Yuan Deng, Jiang-Ning Hu*, The octyl ester of ginsenoside Rh2 induces lysosomal membrane permeabilization via Bax translocation,Nutrients.2016, 8(5): 244-258.

17) Fang Chen, Shi-LianZheng, Jiang-Ning Hu*, Yong Sun, Yue-Ming He, Han Peng, Bing Zhang, David Julian McClements, and Ze-Yuan Deng*,Octyl Ester of Ginsenoside Rh2 Induces Apoptosis and G1 Cell Cycle Arrest in Human HepG2 Cells by Activating the Extrinsic Apoptotic Pathway and Modulating the Akt/p38 MAPK Signaling Pathway, J. Agric. Food Chem.2016, 64 (40), 7520-7529.

18) Fang Chen, Ze-Yuan Deng, Bing Zhang, Zeng-Xing Xiong, Shi-Lian Zheng, Chao-Li Tan, Jiang-Ning Hu*, Esterification of ginsenoside Rh2 enhanced its cellular uptake and antitumor activity in human HepG2 cells,J. Agric. Food Chem.2016. 64, 253-261.

19) Fang Chen, Ze-Yuan De, Zeng-Xing Xiong, Bing Zhang, Jian-Yuan Yang, Jiang-Ning Hu*,A ROS-mediated lysosomal-mitochondrial pathway is induced by ginsenoside Rh2 in hepatoma HepG2 cells,Food & function.2015, 6, 3828-3837.

20) Fang Chen, Yong Tao, Cheng Jin, Yang Xu, Bai-Xue Lin*, Enhanced production of polysialic acid by metabolic engineering of Escherichia coli,.Appl. Microbiol. Biotechnol.,2015, 99: 2603-2611.

专利：

主持的科研项目：

· 20230101-20251231 基于PPAR-γ调控的脂肪酸氧化研究人参皂苷Rh2/Rh2-O诱导肿瘤相关巨噬细胞复极化的分子机制（20224BAB206109），江西省自然科学基金面上项目，10万元，主持

· 20220921-20250921 特殊医学用途配方食品产品研发，横向课题（江西人之初营养科技股份有限公司），5.1万元，主持

· 20210101-20240731，食品添加剂新品种氨基酰化酶和高纯度L-硒-甲基硒代半胱氨酸标准品的制备及申报，横向课题（江西川奇药业有限公司），10万元，主持

· 202101-202312 基于 PI3K/Akt/HIF-1α信号通路研究 Rh2-O 抑制肝癌血管生成的作用（20204BCJ23025），江西省主要学科学术和技术带头人培养计划--青年人才项目，30万元，主持

· 201901-202212 ，基于CRT迁移研究Rh2-O诱导癌细胞的免疫原性死亡分子机制（81860578），国家自然科学地区项目，35万元，主持

· 201901-202112 基于TLR4 /NF-κB信号通路研究人参皂苷Rh2及其辛酸酯衍生物对H22荷瘤小鼠的免疫调节作用及其分子机制（20181BAB215034），江西省自然科学基金青年项目，6万元，主持

· 201901-202112 基于TLR4 /NF-κB信号通路研究人参皂苷Rh2及其辛酸酯衍生物对H22荷瘤小鼠的免疫调节作用及其分子机制（PY2018），南昌大学医学部青年教师科研培育基金，5万元，主持

· 201801-202112 基于计算机模拟和实验研究探索类胡萝卜素和酚类化合物的抗氧化协同作用机理（31760432），国家自然科学基金地区项目，38万元，参与

· 201801-202012 黑豆膳食纤维结合的多酚构成、胃肠道释放规律及其抗氧化效应研究（31701564），国家自然科学基金青年基金，25万元，参与

· 201601-201912 基于量子化学及分子动力学探讨非水相合成OMO型结构脂肪过程中酶催化失活机理及其调控研究（31571870），国家自然科学基金面上项目，68万元，参与

· 2015.09-2016.09 基于“溶酶体-线粒体轴心”理论探讨人生皂苷Rh2 诱发HepG2细胞凋亡机制（Grant YC2014-B016），江西省研究生创新专项资金项目，0.5万元，主持