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硕士生导师介绍

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罗清

发布时间:2023-09-18 03:38:54

姓名:罗清

系别:临床检验诊断学

研究方向:自身免疫、抗感染免疫

工作邮箱:lxc042@163.com

办公电话:0791-88692794


个人简介:

       毕业于南昌大学,现任南昌大学第一附属医院副主任技师、硕士生导师,江西省医学会医学检验学分会第十届委员会青年委员、白求恩精神研究会检验医学分会新媒体专业委员会委员、江西省中西医结合学会第二届检验医学专业委员会委员等。长期从事自身免疫、抗感染免疫研究,主持国家级省级课题9项,以第一作者和通讯作者署名发表学术论文50余篇,荣获江西省科技进步奖二等奖、三等奖各一项,授权国家发明专利三项。


论文、专著与专利:

1)Qing Luo#, Yutao Ye#, Lu Zhang, Yujie Gao, Jiayue Rao, Yang Guo, Qingshui Huang, Zikun Huang*, Junming Li*. Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus. J Immunotoxicol. 2023 Dec;20(1):2196453.

2)Dan Long#, Shujiao Yu#, Lu Zhang, Yang Guo, Shumin Xu, Yuting Rao, Zikun Huang, Qing Luo*, Junming Li*. Increased sIL-2Ra leads to obstruction of IL-2 biological function and Treg cells differentiation in SLE patients via binding to IL-2. Front Immunol. 2022 Sep 20;13:938556.

3)Qing Luo#, Yongqin Guo#, Qiuyun Xiao 2, Biqi Fu 3, Lu Zhang 1, Yang Guo 1, Zikun Huang*, Junming Li*. Expression and Clinical Significance of the m6A RNA-Binding Proteins YTHDF2 in Peripheral Blood Mononuclear Cells From New-Onset Ankylosing Spondylitis. Front Med (Lausanne). 2022;9:922219.

4)Fangyi Yao#, Chuxin Xu#, Yujie Gao, Biqi Fu, Lu Zhang, Yang Guo, Zikun Huang, Xiaozhong Wang, Junming Li*, Qing Luo*. Expression and clinical significance of the m6A reader YTHDF2 in peripheral blood mononuclear cells from rheumatoid arthritis patients. J Immunotoxicol. 2022;19(1):53-60.

5)Qing Luo#, Yunyuan Kong#, Biqi Fu, Xue Li, Qingshui Huang, Zikun Huang*, Junming Li*. Increased TIM-3+PD-1+ NK cells are associated with the disease activity and severity of systemic lupus erythematosus. Clin Exp Med, 2022;22(1):47-56.

6)Yujie Gao#, Fangyi Yao#, Jiayue Rao, Lu Zhang, Yang Guo, Zikun Huang, Qingshui Huang, Junming Li*, Qing Luo*. Circular RNAs hsa-circ0000175 and hsa-circ0044235 in plasma are novel biomarkers for new-onset rheumatoid arthritis. Autoimmunity, 2021, 54(4):234-242.

7)Qing Luo#, Lu Zhang#, Lihong Xiong, Biqi Fu, Yang Guo, Zikun Huang*, Junming Li*, Peripheral blood circular RNA hsa_circ_0082688-hsa_circ_0008675 can be used as a candidate biomarker of systemic lupus erythematosus with renal involvement, Clin Exp Rheumatol, 2020, 38(5):822-833.

8)Qing Luo#, Xue Li#, Biqi Fu, Lu Zhang, Le Fang, Cheng Qing, Yang Guo, Zikun Huang*, Junming Li*. Expression profile and diagnostic value of circRNAs in peripheral blood from patients with systemic lupus erythematosus. Mol Med Rep, 2021, 23(1):1.

9)Qing Luo#, Biqi Fu#, Lu Zhang, Yang Guo, Zikun Huang, Junming Li. Expression and clinical significance of circular RNA hsa_circ_0079787 in the peripheral blood of patients with axial spondyloarthritis. Mol Med Rep. 2020 Nov;22(5):4197-4206.

10)Qing Luo#, Yujie Gao#, Lu Zhang, Jiayue Rao, Yang Guo, Zikun Huang*, Junming Li*, Decreased ALKBH5, ALKBH5, and YTHDF2 in Peripheral Blood Are as Risk Factors for Rheumatoid Arthritis, Biomed Res Int, 2020, 2020:5735279.

11)Qing Luo#, Biqi Fu#, Lu Zhang, Yang Guo, Zikun Huang*, Junming Li*, Decreased Peripheral Blood ALKBH5 Correlates with Markers of Autoimmune Response in Systemic Lupus Erythematosus, Dis Markers, 2020, 2020:8193895.

12)Qing Luo#, Jiayue Rao#, Lu Zhang, Biqi Fu, Yang Guo, Zikun Huang*, Junming Li*, The study of METTL14, ALKBH5, and YTHDF2 in peripheral blood mononuclear cells from systemic lupus erythematosus, Mol Genet Genomic Med, 2020, 8(9):e1298.

13)Qing Luo#, Lulu Zeng#, Lingbing Zeng, Jiayue Rao, Lu Zhang, Yang Guo, Zikun Huang*, Junming Li*, The expression of circular RNAs hsa_circ_0000175 and hsa_circ_0008410 in peripheral blood mononuclear cells from rheumatoid arthritis and clinical significance, Int J Mol Med, 2020, 45(4): 1203-1212.

14)Qing Luo#, Lu Zhang#, Le Fang, Biqi Fu, Yang Guo, Zikun Huang*, Junming Li*, Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus, Autoimmunity, 2020, 53(3):167-176.

15)Qing Luo#, Jun Liu#, Biqi Fu, Lu Zhang, Yang Guo, Zikun Huang*, Junming Li*, Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis, Dis Markers, 2019, 2073139.

16)Qing Luo#, Lu Zhang#, Xue Li, Biqi Fu, Yang Guo, Zikun Huang*, Junming Li*, Identification of circular RNAs hsa_circ_0044235 and hsa_circ_0068367 as novel biomarkers for systemic lupus erythematosus, Int J Mol Med, 2019, 44(4):1462-1472.

17)Qing Luo#, Fangyi Yao#, Lu Zhang, Xue Li, Cheng Qing, Rigu Su, Yang Guo, Zikun Huang*, Junming Li*. Elevated expression of Pglyrp1 in peripheral blood mononuclear cells and PGLYRP-1 in serum from systemic lupus erythematosus patients. Int J Clin Exp Med 2019;12(4):3398-3408.

18)Qing Luo#, Xue Li#, Lu Zhang, Fangyi Yao, Zhen Deng, Cheng Qing, Rigu Su, Jianqing Xu, Yang Guo, Zikun Huang*, Junming Li*, Serum PGLYRP-1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis, Mol Med Rep, 2019, 19(1): 589-594.

19)Qing Luo#, Lu Zhang#, Xue Li, Biqi Fu, Zhen Deng, Cheng Qing, Rigu Su, Jianqing Xu, Yang Guo, Zikun Huang*, Junming Li*, Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for rheumatoid arthritis, Clin Exp Immunol, 2018, 194(1):118-124.

20)Qing Luo, Pengcheng Xiao, Xue Li, Zhen Deng, Cheng Qing, Rigu Su, Jianqing Xu, Yang Guo, Zikun Huang*, Junming Li*. Overexpression of CD64 on CD14++CD16‑ and CD14++CD16+ monocytes of rheumatoid arthritis patients correlates with disease activity. Exp Ther Med. 2018 Sep;16(3):2703-2711.

21)Qing Luo#, Xue Li#, Biqi Fu, Lu Zhang, Zhen Deng, Cheng Qing, Rigu Su, Jianqing Xu, Yang Guo, Zikun Huang, Junming Li. Decreased expression of TIGIT in NK cells correlates negatively with disease activity in systemic lupus erythematosus. Int J Clin Exp Pathol 2018;11(5):2408-2418.

22)Qing Luo#, Jianqing Ye#, Lulu Zeng, Zhongqin Luo, Zhen Deng, Xue Li, Yang Guo, Zikun Huang*, Junming Li*, Elevated expression of PD-1 on T cells correlates with disease activity in rheumatoid arthritis, Mol Med Rep, 2018, 17(2): 3297-3305.

23)Qing Luo#, Chuxin Xu#, Xue Li, Lulu Zeng, Jianqing Ye, Yang Guo, Zikun Huang*, Junming Li*. Comprehensive analysis of long non-coding RNA and mRNA expression profiles in rheumatoid arthritis. Exp Ther Med. 2017 Dec;14(6):5965-5973.

24)Qing Luo#, Xue Li#, Chuxin Xu, Lulu Zeng, Jianqing Ye, Yang Guo, Zikun Huang*, Junming Li*. Integrative analysis of long non-coding RNAs and messenger RNA expression profiles in systemic lupus erythematosus. Mol Med Rep. 2018 Mar;17(3):3489-3496.

25)Qing Luo#, Lulu Zeng#, Hanying Mei, Zikun Huang*, Zhongqin Luo, Jianqing Ye, Xue Li, Yang Guo, Junming Li*. PD-L1-expressing neutrophils as a novel indicator to assess disease activity of rheumatoid arthritis. Int J Clin Exp Med 2017;10(5):7716-7724.

26)Qing Luo#, Jianqing Ye#, Lulu Zeng, Xue Li, Le Fang, Beihua Ju, Zikun Huang*, Junming Li*, Elevated expression of TIGIT on CD3+CD4+ T cells correlates with disease activity in systemic lupus erythematosus, Allergy Asthma Clin Immunol, 2017, 13:15.

27)Qing Luo#, Zhen Deng#, Chuxin Xu, Lulu Zeng, Jianqing Ye, Xue Li, Yang Guo, Zikun Huang*, Junming Li*. Elevated Expression of Immunoreceptor Tyrosine-Based Inhibitory Motif (TIGIT) on T Lymphocytes is Correlated with Disease Activity in Rheumatoid Arthritis. Med Sci Monit. 2017 Mar 10;23:1232-1241.

28)Qing Luo#, Zikun Huang, Jianqing Ye, Yating Deng, Le Fang, Xue Li, Yang Guo, Hong Jiang, Beihua Ju, Qingshui Huang, Junming Li*, PD-L1-expressing neutrophils as a novel indicator to assess disease activity and severity of systemic lupus erythematosus, Arthritis Res Ther, 2016, 18:47.

29)Qing Luo#, Peng Fu#, Yongqin Guo, Biqi Fu, Yang Guo, Qingshui Huang, Zikun Huang*, Junming Li*. Increased TIGIT+PD‑1+CXCR5‑CD4+T cells are associated with disease activity in rheumatoid arthritis. Exp Ther Med. 2022 Aug 31;24(4):642.

30)黄自坤,高玉洁,罗清*.血浆环状RNA hsa_circ_0034398在系统性红斑狼疮中的表达和意义. 中国免疫学杂志. 2023,39(01):109-115.

31)黄自坤, 张露, 李雪, 罗清*. 类风湿关节炎患者外周血TFH细胞TIGIT和PD1表达及意义. 安徽医科大学学报. 2023,58(05): 838-844.

32)罗清; 张露; 黄自坤; 符碧琪; 李俊明.系统性红斑狼疮患者外周血CXCR5-CD4+T细胞上PD1表达及意义. 安徽医科大学学报. 2023,58(07):1103-1110.

33)罗清; 涂丽娜; 符碧琪; 李雪; 李俊明.类风湿关节炎患者外周血CXCR5- CD4+T细胞上PD1表达及意义. 安徽医科大学学报. 2022,57(12):1891-1895.

34)罗清,黄自坤,李雪,李俊明,系统性红斑狼疮外周血T淋巴细胞PD-1和Tim-3表达和意义,中国免疫学杂志,2022,38(14):1744-1749.

35)罗清,黄自坤,张露,李俊明,环状RNA hsa_circ_0004156 和hsa_circ_0082626 在系统性红斑狼疮患者全血中的表达及临床意义,中国免疫学杂志,2020,36(20):2500-2510.

36)罗清,黄自坤,张露,李俊明,环状RNA hsa_circ_0002715在系统性红斑狼疮患者全血中的表达和意义. 安徽医科大学学报, 2020, 55( 7):1130-1136.

37)黄自坤,曾璐璐,罗 清*,系统性红斑狼疮患者外周血NK细胞TIM-3表达和意义,免疫学杂志,2020,36(3):248-253.

38)罗清,张露,黄自坤,李俊明,CDC27基因在系统性红斑狼疮中的表达和临床意义,安徽医科大学学报, 2020, 55( 2):292-295.

39)黄自坤,张露,曾璐璐,罗清*. 环状RNA hsa_circ_104871在系统性红斑狼疮患者外周血单个核细胞中的表达和意义. 安徽医科大学学报,2019, 54(12):1947-1951.

40)原发性胆汁性胆管炎实验室检测及诊断的临床意义.实验与检验医学,2019,37(3):419-429.

41)黄自坤,黄清水,李雪,鞠北华,罗 清*,CD64在RA患者单核细胞中的表达及与TNF-α的相关性研究.安徽医科大学学报,2019, 54(2):281-285.

42)黄自坤,曾璐璐,罗 清*,系统性红斑狼疮外周血NK 细胞PD-1 的表达及意义,广东医学,2018,39(22):3324-3329.

43)崔星羽,梁从碧,陈慧芳,艾文倩,罗 清*,6804例抗线粒体抗体检测的临床分析,实验与检验医学,2018,36(4):563-565.

44)李雪,黄自坤,邓桢,罗 清*,系统性红斑狼疮患者外周血NK细胞TIGIT的表达和意义,免疫学杂志,2018,34(7):607-611.

45)黄自坤,李雪,罗 清*,类风湿关节炎单核巨噬细胞极化表型分析及临床意义,安徽医科大学学报,2018,53(4):605-609.

46)李雪,罗 清*,巨噬细胞极化在类风湿关节炎中的作用,生命科学,2018,30(3):261-266.

47)黄自坤,李雪,邓桢,罗清*,类风湿关节炎外周血单核细胞亚群 CD64 表达及意义,中国免疫学杂志,2018,34(1):77-83.

48)黄自坤,李雪,鞠北华,罗 清*,类风湿关节炎患者外周血T细胞PD1的表达分析和意义,安徽医科大学学报,2017,52(12):1854-1859.

49)黄自坤,李 雪,罗忠勤,罗 清*,类风湿性关节炎外周血中性粒细胞PD-L1表达及意义,免疫学杂志,2017,33(07):586-590.

50)黄自坤,罗忠勤,李雪,罗 清*,系统性红斑狼疮患者外周血CD4+T细胞TIGIT的表达和意义,免疫学杂志,2017,33(6):512-518.

51)黄自坤,李雪,邓桢,罗忠勤,鞠北华,罗 清*,类风湿关节炎患者外周血 CD4+ T 和 CD8+ T细胞TIGIT的表达和意义,中华微生物学和免疫学杂志,2017,37(5):325-332.

52)姚芳苡,黄自坤,李雪,叶建青,罗 清*,系统性红斑狼疮患者外周血中性粒细胞PD-L1表达和临床意义,安徽医科大学学报,2017,52(5):740-745.


主持的科研项目:

1.2022.1-2025.12,国家自然科学基金(82160307),“ALKBH5介导的中性粒细胞自噬在RA发生发展中的作用及机制研究”,35万

2.2023.1-2025.12,江西省自然科学基金项目(20224BAB216038),“m6a修饰circFOXK2调节CD4+T细胞功能在RA发生发展中的作用及机制研究”,10万

3.2018.01-2020.12,江西省重点研发计划(20181BBG70013),“血浆环状RNA(circRNA)作为系统性红斑狼疮筛查分子标志物的研究”,20万元

4.2018.01-2019.12,江西省教育厅科技项目(GJJ17008),“全血环状RNA(circRNA)作为系统性红斑狼疮筛查分子标志物的研究”,5万元

5.2017.01-2019.12,江西省自然科学基金项目(20171BAB205113),“Tfh细胞表面负性共刺激分子TIGIT在SLE发生和发展中的作用及其调控机制”,6万元。

6.2015.01-2017.12,江西省自然科学基金项目(20151BAB215031),“中性粒细胞负性共刺激分子PD-L1在RA发生和发展中的作用及其调控机制”,5万元。

7.2014.01-2017.12,国家自然科学基金项目(81360459),“巨噬细胞的极化改变在RA发生和发展中的作用及其调控机制研究”,45万元。

8.2016.01-2017.12,江西省卫生厅课题(20165094),“特异性IgG亚类ANA(MND和M)对PBC诊断及预后判断的作用研究”,0万元。