【个人信息】

姓名：邓立彬

电子邮箱： lbdeng@ncu.edu.cn

所属部门： 公共卫生学院

职  称：教授

一、研究方向

（1）研究方向：医学大数据分析

（2）主要研究领域：统计学方法在医学中的应用

二、任教课程

医学统计学

三、 学术简历

2004.09-2007.07：中国科学院，北京基因组研究所，理学博士

2001.09-2004.07：华中科技大学同济医学院，法医教研室，理学硕士

1996.09-2001.07：同济医科大学，公共卫生学院，医学学士

2021.12至今，南昌大学，公共卫生学院，教授

2019.07年2021.11，南昌大学，公共卫生学院，副教授

2009.07年2019.07，南昌大学，基础医学院，副教授

2007.07-2008.07，中国科学院，北京基因组研究所，助理研究员

四、 学术兼职

江西省细胞生物学学会 理事

江西省医学会遗传学分会 常务委员

江西省医学会大数据与人工智能分会 常务委员

五、 荣誉奖励

2011年获评“江西省高校第七批中青年骨干教师”

2013年获评“江西省青年科学家培养对象”

六、 代表性成果

（一）主要论著：

• 1.Dai F, Liu Q, Guo Y, Xie R, Wu J, Deng T, Zhu H, Deng L#, Song L#. (2024). Convolutional neural networks combined with

  classification algorithms for the diagnosis of periodontitis. Oral Radiol. Online ahead of print.

• 2.Zhu Q, Dai H, Qiu F, Lou W, Wang X, Deng L#, Shi C#. (2024). Heterogeneity of computational pathomic signature predicts

  drug resistance and intra-tumor heterogeneity of ovarian cancer. Transl Oncol. 40:101855.

• 3.Liu Q, Dai F, Zhu H, Yang H, Huang Y, Jiang L, Tang X, Deng L, Song L. (2023). Deep learning for the early identification of

  periodontitis: a retrospective, multicentre study. Clin Radiol. 78(12):e985-e992.

• 4.Xu Z, Xi F, Deng X, Ni Y, Pu C, Wang D, Lou W, Zeng X, Su N, Chen C, Zeng Z, Deng L#, Jiang M#. (2023). Osteopontin

  Promotes Macrophage M1 Polarization by Activation of the JAK1/STAT1/HMGB1 Signaling Pathway in Nonalcoholic Fatty

  Liver Disease. J Clin Transl Hepatol. 11(2):273-283.

• 5.Zeng Z, Wang Q, Yu Y, Zhang Y, Chen Q, Lou W, Wang Y, Yan L, Cheng Z, Xu L, Yi Y, Fan G, Deng L#. (2022). Assessing

  electrocardiogram changes after ischemic stroke with artificial intelligence. PLoS One. 17(12):e0279706.

• 6.Li M, Liu Y, Liu Y, Pu C, Yin R, Zeng Z, Deng L#, Wang X#. (2022). Resting-state EEG-based convolutional neural network

  for the diagnosis of depression and its severity.  Front Physiol. 13:956254.

• 7.Duan S*, Gao J*, Lou W, Zhang Y, Deng Y, Wang C, Huang H, Xu H , Guo S, Lai S, Xi F , Li Z, Deng L#, Zhong Y#. (2022).

  Prognostic signature for hepatocellular carcinoma based on 4 pyroptosis-related genes. BMC Med Genomics. 15(1):166.  

• 8.Deng L*, Xu J*, Chen W, Guo S, Steiner R, Chen Q, Cheng Z, Xu Y, Yao Y, Li X, Wang X, Deng K, Schrodi S, Zhang D#, Xin H#.

  (2021). Remediation of ABCG5- Linked Macrothrombocytopenia With Ezetimibe Therapy. Front Genet. 12:769699.

• 9.Liu Z*, Wu H*, Deng J*, Wang H, Wang Z, Yang A, Liang B, Luo J, Li J, Xu Y, Tang X, Fu F#, Deng L#. (2020). Molecular

  classification and immunologic characteristics of immunoreactive high-grade serous ovarian cancer. J Cell Mol Med.

  24: 8103~8114.

• 10.Xu Y, Li J, Yang W, Tang X, Huang B, Liu J, Lin J, Zhang J, Yang W, Li S, Sun F, Deng L#, Wang X#. (2020). A Pooling Genome

  -Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han

  Population. Int J Genomics.2020:7531876.

• 11.Chen S*, Liu M*, Liang B*, Ge S, Peng J, Huang H, Xu Y, Tang X, Deng L#. (2020). Identification of human peripheral blood

  monocyte gene markers for early screening of solid tumors. PLoS One. 15(3):e0230905.

• 12.Sima X, He J, Peng J, Xu Y, Zhang F, Deng L#. (2019). The genetic alteration spectrum of the SWI/SNF complex: The

  oncogenic roles of BRD9 and ACTL6A. PLoS One. 14(9): e0222305.

• 13.Cheng Z, Wen Y, Liang B, Chen S, Liu Y, Wang Z, Cheng J, Tang X, Xin H, Deng L#. (2019). Gene expression profile-based

  drug screen identifies SAHA as a novel treatment for NAFLD. Molecular Omics, 15(1): 50~58.

• 14.Shi C*, Xu H*, Liu J, Zhong Y, Zhang X, Tong X, Zhang L, Li X, Deng L#. (2019). Alternatively activated NUSAP1 promotes

  tumor growth and indicates poor prognosis in hepatocellular carcinoma. Transl Cancer Res, 8(1): 238~247.

• 15.Deng L*, Huo L*, Zhang J, Tang X, Cheng Z, Li G, Fang X, Xu J, Zhang X, Xu R. (2017). Polymorphism of rs3737597 in

  DISC1 Gene on Chromosome 1q42.2 in sALS Patients: a Chinese Han Population. Mol Neurobiol, 54(5):3162~3180.

• 16.Deng L, Zhang C, Miao D, Tang X, Luo S, Xin HB, Shi H. (2017). Mediator complex components are frequent targets for

  genetic alteration in various types of human cancer. J. Genet. Genomics, 44(12):587-591.

• 17.Hu Y*, Deng L*, Zhang J*, Fang X, Mei P, Cao X, Lin J, Wei Y, Zhang X, Xu R. (2016). A Pooling Genome-Wide Association

  Study Combining a Pathway Analysis for Typical Sporadic Parkinson's Disease in the Han Population of Chinese Mainland.

  Mol Neurobiol, 53(7):4302-18.

• 18.Tang X*, Deng L*, Xiong H*, Li G*, Lin J, Liu S, Xie J, Liu J, Kong F, Tu G, Peng H, Liang S*. (2014). Expression Profiles of

  Skeletal Muscle and Liver Implicate MAPK Signaling Pathways in Diabetes Pathology. INDIAN J MED RES, 140(6):744-755.

• 19.Xie T*, Deng L*, Mei P, Zhou Y, Wang B, Zhang J, Lin J, Wei Y, Zhang X*, Xu R*. (2014). A genome-wide association study

  combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. Neurobiol

  Aging, 35(7):1778.e9-1778.e23.

• 20.Tang X*, Deng L*, Zhang D, Lin J, Wei Y, Zhou Q, Li X, Li G, Liang S. (2012). Gene2DGE: a Perl package for gene model

  renewal with digital gene expression data. Genomics Proteomics Bioinformatics, 10(1):51-4.

• 21.Gao Y*, Liu H*, Deng L*, Zhu G*, Xu C, Li G, Liu S, Xie J, Liu J, Kong F, Wu R, Li G, Liang S. (2011). Effect of emodin on

  neuropathic pain transmission mediated by P2X(2/3) receptor of primary sensory neurons. Brain Res Bull, 84(6):406-13.

• 22.Deng L, Tang X, Hao X, Chen W, Yu Y, Zhang D, Zeng C. (2011). Genetic Flux Between H1 and H2 Haplotypes of the

  17q21.31 Inversion in European Population. Genomics. Proteomics & Bioinformatics, 9(3): 113-118.

• 23.Deng L, Tang X, Chen W, Lin J, Lai Z, Liu Z, Zhang D. (2010). Scanning for Genomic Regions Subject to Selective Sweeps

  Using SNP-MaP Strategy. Genomics Proteomics Bioinformatics, 8(4): 256-261.

• 24.Deng L, Zhang D, Richards E, Tang X, Long F, Fang J, Wang Y. (2009) Constructing an initial map of transmission distortion

  based on high density HapMap SNPs across the human autosomes. J. Genet. Genomics, 36(12): 703-709.

• 25.Deng L, Zhang Y, Kang J, Liu T, Zhao H, Gao Y, Li C, Pan H, Tang X, Wang D, Niu T, Yang H, Zeng C. (2008). An Unusual

  Haplotype Structure on Human Chromosome 8p23 Derived from the Inversion Polymorphism. Hum Mutat, 29(10): 1209-1216.

• 26.Deng L, Tang X, Kang J, Wang Q and Zeng C. (2007). Scanning for signatures of geographically restricted selection based on

  population genomics analysis. Chinese Sci. Bull, 52(19): 2649-2656.   (中文版：邓立彬，汤晓丽，康健，王青芸，曾长青；（2007）；

  利用群体基因组学策略扫描人群特异的自然选择信号；科学通报，52(18)：2127-2133)

• 27.Luo C*, Deng L*, and Zeng C. (2004). High throughput SNP genotyping with two mini-sequencing assays. Acta Biochim.

  Biophys. Sin, 36: 379-384.

• 28.Luo C*, Deng L*, Zhou J, Lin W and Zeng C. (2004). High throughput SNP genotyping with FP-TDI. Prog. Biochem.

  Biophys, 31(8): 731-735.

（二）专利及著作权:

• 1.一种卵巢癌分子分型预测系统. 邓立彬,王豪庆,梁博文,王紫璇,杨霭琳,傅芬,汤晓丽. 中国ZL 2018 1 1389851.4. 2021/9/24 (发明专利)

• 2.一种基于卷积神经网络的牙周炎智能检测方法及系统. 邓立彬,宋莉,葛尚华,刘强冬,戴芳,娄伟明,李璨,杨晶晶,陈霖佳,彭捷,田菊,

  吴婧婷,邹源,俞晴. 中国ZL 2020 1 0966941.6 2022/8/30 (发明专利)

• 3.基于CNN的牙周炎分期分级系统V1.0. 邓立彬；宋莉；戴芳；葛尚华；南昌大学第二附属医院. 2021SR0915429. 2021/6/18 (著作权)

• 4.一种基于心电图像的帕金森预测智能化方法及系统. 邓立彬,范广勤,冯昶,王钰婷,娄伟明,张伊楚,谢锐翔,黄卫.

  CN202111580521.5. 2021/12/22 (发明专利)

• 5.一种基于病理图像的卵巢癌患者化疗敏感性的预测方法及系统. 邓立彬,娄伟明,汤晓丽,刘越,葛尚华,邬以国,高建莹,傅芬,石超.

  CN202111487778.6. 2021/12/7 (发明专利)

七、 代表性项目

• 1. 2021.1-2024.12：国家自然科学基金地区项目“PTMA通过改变肝细胞组蛋白修饰促进NAFLD的作用机制”（82060112）

• 2017.1-2020.12：国家自然科学基金地区项目“PPARA相关rSNP的组学筛查及其在高胆固醇血症中的协同致病机制”（81660041）

• 2013.1-2016.12：国家自然科学基金地区项目“家族性高胆固醇血症相关功能突变的组学筛查及基因敲除小鼠模型的建立”（81260021）

• 2009.1-2011.12：国家自然科学基金面上项目“正选择在人群分化及中国人特异遗传背景形成中作用的研究”（30871384）

• 2018.01-2020.12：江西省自然科学基金面上项目“rSNP在PPAR信号通路紊乱致高胆固醇血症中的机制探讨”（20181BAB205008）

• 2012.01-2014.12：江西省自然科学基金青年项目“肝脏免疫相关通路在大鼠高糖高脂耐受机制中的作用”（20114BAB215019）

• 2013.01-2015.12：江西省教育厅面上项目“汉族人体质表型特征关联的遗传标记发现和功能推断（GJJ13091）

• 2010.01-2011.12：江西省教育厅面上项目“江西人群老年痴呆候选基因多态性普查及风险预测”（GJJ10303）

• 2017.11-.2019.11：江西省研究生教育创新计划项目“大数据背景下医学研究生《生物信息学》创新教学的探索和实践”（JXYJG-2017-016）