Personal Information

Name: Xian Hao

Email: xian.hao@ncu.edu.cn

Department: Department of Medical Laboratory and Quarantine, Teaching and Research Office of Sanitary Chemistry, School of Public Health, Nanchang University

Title: Professor

I. Research Directions

(1) Research Focus: Sanitary Chemistry; Detection and Assessment of Health Risk Factors

(2) Main Research Areas: Research on early detection methods for major infectious diseases; Development of single-molecule technologies and their application in chromosome conformation analysis.

II. Academic Profile

·Apr 2019 – Present: Professor, Doctoral Supervisor, School of Public Health, Medical Department, Nanchang University

·Nov 2015 – Mar 2019: Roux-Cantarini Fellow, Postdoctoral Researcher, Institut Pasteur, France

·Apr 2014 – Sep 2015: Postdoctoral Researcher, University of California, Merced, USA

·Jan 2013 – Mar 2014: Postdoctoral Researcher, University of Houston, USA

·Feb 2012 – Dec 2012: Project Assistant Researcher, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

·Feb 2011 – Jan 2012: Postdoctoral Researcher, Technical University of Denmark

·Sep 2007 – Jan 2011: Ph.D. in Science, Graduate School of the Chinese Academy of Sciences (Changchun Institute of Applied Chemistry)

·Sep 2005 – Jun 2007: M.S. in Science, China University of Geosciences (Beijing)

·Jul 2001 – Aug 2005: Research Assistant, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

·Sep 1997 – Jun 2001: B.S. in Science, China University of Geosciences (Beijing)

III.Honors and Awards

·2014: Roux-Cantarini Fellow, Institut Pasteur

·2005: Third Prize for Science and Technology Progress of Jilin Province

IV. Representative Achievements

(I) Selected Publications:

1.Jiawei Peng, Ting Liu, Liwen Guan, Ziyue Xu, Ting Xiong, Yu Zhang, Jiaxin Song, Xuexia Liu, Yifei Yang, and Xian Hao*. A Highly Sensitive Lock-Cas12a Biosensor for Detection and Imaging of Mirna-21 in Breast Cancer Cells. Talanta125938.doi.org/10.1016/j.talanta.2024.125938

2.Liwen Guan, Jiawei Peng, Ting Liu, Shuangyi Huang, Yifei Yang, Xiaolei Wang* and Xian Hao*, Ultrasensitive miRNA Detection Based on Magnetic Upconversion Nanoparticles Enhancement and CRISPR/Cas13a-driven Signal Amplification, Analytical Chemistry2023, 95, 17708−17715

3.Ziyue Xu, Liwen Guan, Jiawei Peng, Shuangyi Huang, Ting Liu, Ting Xiong, Yifei Yang , Xiaolei Wang, Xian Hao, Ultra-sensitive and specificity quantitative detection of miRNA using a combined CRISPR/Cas13a and DNA-PAINT, Sensors and Actuators: B. Chemical2023, 395, 134451

4.Chaonan He, Xiaorong Liu, Meng Yu, Zhuang Qiu, Tong Huang, Weichang Xie, Haoxin Cheng, Yifei Yang, Xian Hao* and Xiaolei Wang*, Smartphone conducted DNA portable quantitative detection platform based on photonic crystals chip and magnetic nanoparticles. Talanta2023, 124849.

5.Xiaorong Liu, Chaonan He, Qi Huang, Mengmeng Yu, Zhuang Qiu, Haoxin Cheng, Yifei Yang, Xian Hao* and Xiaolei Wang*, A facile visualized solid-phase detection of virus-specific nucleic acid sequences through an upconversion activated linear luminescence recovery process. Analyst2022, 147 (11), 2378-2387. (Analyst HOT Articles 2022, CAS Zone 2)

6.Xian Hao#, Jyotsana J Parmar#, Benoît Lelandais#, Andrey Aristov, Wei Ouyang, Christian Weber, Christophe Zimmer, Super-resolution visualization and modeling of human chromosomal regions reveals cohesin-dependent loop structures, Genome Biology, 2021, 22(1): 150. (CAS Zone 1, Top Journal)

7.Xian Hao, Jingdong Zhang, Yifei Yang, Hongda Wang, Qijin Chi, Single-Molecule Interactions between Heme Proteins and Carboxylic Groups in Various Chemical Environments. ChemElectroChem, 2020, 7(21): 4441-4445.

8.Wei Ouyang, Andrey Aristov, Mickeal Lelek, Xian Hao & Christrophe Zimmer. Deep learning massively accelerates super-resolution localization microscopy. Nature Biotechnology2018, 36, 460.

9.Xian Hao, Eric A Josephs, Qufei Gu and Tao Ye, Molecular Conformations of DNA Targets Captured by Model Nanoarrays. Nanoscale, 2017, 9, 13419-13424.

10.Xian Hao, Nan Zhu, Tina Gschneidtner, Elvar Ö. Jonsson, Jingdong Zhang, Kasper Moth-Poulsen, Hongda Wang, Kristian S. Thygesen, Karsten W. Jacobsen, Jens Ulstrup, Qijin Chi, Direct Measurement and Modulation of Single-molecule Coordinative Bonding Forces in a Transition Metal Complex, Nature Communications, 4 (2013), 2121.

11.Heng Liu#, Xian Hao#, Chunhui Duan#, Hui Yang#, Yi Lv, Haijiao Xu, Hongda Wang, F. Huang, Debao Xiao and Zhiyuan Tian. Al3+-Induced Far-red Fluorescence Enhancement of Conjugated Polymer Nanoparticles and Its Application in Live Cell Imaging, Nanoscale, 5 (2013), 9340-9347.

12.Heng Liu#, Hui Yang#, Xian Hao#, Haijiao Xu, Yi Lv, Debao Xiao, Hongda Wang, and Zhiyuan Tian, Development of Polymeric Nanoprobes with Improved Lifetime Dynamic Range and Stability for Intracellular Oxygen Sensing, Small, 9 (2013),2639-2648.

13.Xian Hao, Xin Shang, Jiazhen Wu, Yuping Shan, Mingjun Cai, Junguang Jiang, Zhong Huang, Zhiyong Tang and Hongda Wang. Single-Particle Tracking of Hepatitis B Virus-like Vesicle Entry into Cells, Small, 7 (2011), 1212-1218.

14.Junguang Jiang#, Xian Hao#, Mingjun Cai, Yuping Shan, Xin Shang, Zhiyong Tang, and Hongda Wang. Localization of Na+-K+ATPases in Quasi-Native Cell Membranes, Nano Letters, 9 (2009): 4489-4493. (CAS Zone 1, Top Journal)

(II) Patents:

1.Hao Xian, Yu Mengmeng, Yang Yifei, Qiu Zhuang, Liu Xiaorong, He Chaonan, Liu Ting. A preparation method of a multi-fluorescence nucleic acid probe and its application. China Invention Patent, Patent No.: ZL202110165996.1

2.Liu Yayan, Hao Xian, Huan Yan, Yang Yifei, Guo Chuan. Preparation method of polyvinylidene fluoride piezoelectric tube. China Invention Patent, Patent No.: CN100411858C

3.Liu Yayan, Yang Yifei, Hao Xian, Dou Baisheng. Preparation method of strontium barium niobate ceramic powder. China Invention Patent, Patent No.: CN100386290C

4.Liu Yayan, Zhang Fengtao, Hao Xian, Li Ying. Apparatus for ordered orientation of polymeric piezoelectric materials. China Invention Patent, Patent No.: CN1545149A

5.Liu Yayan, Guo Hongxia, Hao Xian, Li Ying. Preparation method of stable lead zirconate titanate sol. China Invention Patent, Patent No.: CN1451632A

6.Wang Lan, Zhou Zhijie, Zhao Wei, Liu Yayan, Hao Xian. Method for producing magnesium oxide single crystals using boron mud. China Invention Patent, Patent No.: CN1546746A

7.Liu Yayan, Zeng Xionghui, Guo Hongxia, Hao Xian, Wang Lan. Barium lead titanate ceramic powder and its preparation method. China Invention Patent, Patent No.: CN1378998A

V. Representative Research Projects

1.2023-2026: National Natural Science Foundation General Program "Visualizing and Analyzing Higher-Order Chromosome Structures Using Single-Molecule Technologies", No. 22277047, ¥540,000, Principal Investigator, Ongoing.

2.2022-2025: National Natural Science Foundation Regional Program "Research on Early Detection Methods for Schistosomiasis Based on CRISPR Technology", No. 82160631, ¥340,000, Principal Investigator, Ongoing.

3.2020-2024: Jiangxi Provincial Long-term Program for Leading Talents in Innovation, ¥2,000,000, Principal Investigator, Ongoing.

4.2019-2024: Nanchang University Discipline Leader Start-up Fund, ¥3,000,000, Principal Investigator.

5.2013-2015: National Natural Science Foundation Youth Program "Study on the Interaction between Rabies Virus and Host Cells Using Single-Particle Tracking Methods", ¥270,000, Principal Investigator, Completed.