Personal Information

Name: Libin Deng

Email: lbdeng@ncu.edu.cn

Department: School of Public Health

Title: Professor

I. Research Directions

(1) Research Focus: Medical Big Data Analysis

(2) Main Research Areas: Application of Statistical Methods in Medicine

II. Teaching Courses

Medical Statistics

III. Academic Profile
·2021.12 - Present: Professor, School of Public Health, Nanchang University

·2019.07 - 2021.11: Associate Professor, School of Public Health, Nanchang University

·2009.07 - 2019.07: Associate Professor, School of Basic Medical Sciences, Nanchang University

·2007.07 - 2008.07: Assistant Research Fellow, Beijing Institute of Genomics, Chinese Academy of Sciences

·2004.09 - 2007.07: Ph.D. in Science, Beijing Institute of Genomics, Chinese Academy of Sciences

·2001.09 - 2004.07: M.S. in Science, Tongji Medical College, Huazhong University of Science and Technology

·1996.09 - 2001.07: B.M. in Medicine, School of Public Health, Tongji Medical University

IV. Academic Affiliations

·Council Member, Jiangxi Society of Cell Biology

·Standing Committee Member, Jiangxi Medical Association, Division of Genetics

·Standing Committee Member, Jiangxi Medical Association, Division of Big Data and Artificial Intelligence

V. Honors and Awards

·Recognized as a "Key Young/Middle-aged Backbone Teacher of Jiangxi Higher Education Institutions (7th Batch)" in 2011.

·Selected as a "Young Scientist Training Candidate in Jiangxi Province" in 2013.

VI. Representative Achievements

(I) Selected Publications:

1.Dai F, Liu Q, Guo Y, Xie R, Wu J, Deng T, Zhu H, Deng L#, Song L#. (2024). Convolutional neural networks combined with classification algorithms for the diagnosis of periodontitis. Oral Radiol. Online ahead of print.

2.Zhu Q, Dai H, Qiu F, Lou W, Wang X, Deng L#, Shi C#. (2024). Heterogeneity of computational pathomic signature predicts drug resistance and intra-tumor heterogeneity of ovarian cancer. Transl Oncol. 40:101855.

3.Liu Q, Dai F, Zhu H, Yang H, Huang Y, Jiang L, Tang X, Deng L, Song L. (2023). Deep learning for the early identification of periodontitis: a retrospective, multicentre study. Clin Radiol. 78(12):e985-e992.

4.Xu Z, Xi F, Deng X, Ni Y, Pu C, Wang D, Lou W, Zeng X, Su N, Chen C, Zeng Z, Deng L#, Jiang M#. (2023). Osteopontin Promotes Macrophage M1 Polarization by Activation of the JAK1/STAT1/HMGB1 Signaling Pathway in Nonalcoholic Fatty Liver Disease. J Clin Transl Hepatol. 11(2):273-283.

5.Zeng Z, Wang Q, Yu Y, Zhang Y, Chen Q, Lou W, Wang Y, Yan L, Cheng Z, Xu L, Yi Y, Fan G, Deng L#. (2022). Assessing electrocardiogram changes after ischemic stroke with artificial intelligence. PLoS One. 17(12):e0279706.

6.Li M, Liu Y, Liu Y, Pu C, Yin R, Zeng Z, Deng L#, Wang X#. (2022). Resting-state EEG-based convolutional neural network for the diagnosis of depression and its severity. Front Physiol. 13:956254.

7.Duan S, Gao J, Lou W, Zhang Y, Deng Y, Wang C, Huang H, Xu H , Guo S, Lai S, Xi F , Li Z, Deng L#, Zhong Y#. (2022).Prognostic signature for hepatocellular carcinoma based on 4 pyroptosis-related genes. BMC Med Genomics. 15(1):166.

8.Deng L, Xu J, Chen W, Guo S, Steiner R, Chen Q, Cheng Z, Xu Y, Yao Y, Li X, Wang X, Deng K, Schrodi S, Zhang D#, Xin H#.(2021). Remediation of ABCG5- Linked Macrothrombocytopenia With Ezetimibe Therapy. Front Genet. 12:769699.

9.Liu Z, Wu H, Deng J*, Wang H, Wang Z, Yang A, Liang B, Luo J, Li J, Xu Y, Tang X, Fu F#, Deng L#. (2020). Molecular classification and immunologic characteristics of immunoreactive high-grade serous ovarian cancer. J Cell Mol Med.24: 8103~8114.

10.Xu Y, Li J, Yang W, Tang X, Huang B, Liu J, Lin J, Zhang J, Yang W, Li S, Sun F, Deng L#, Wang X#. (2020). A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population. Int J Genomics.2020:7531876.

11.Chen S, Liu M, Liang B*, Ge S, Peng J, Huang H, Xu Y, Tang X, Deng L#. (2020). Identification of human peripheral blood monocyte gene markers for early screening of solid tumors. PLoS One. 15(3):e0230905.

12.Sima X, He J, Peng J, Xu Y, Zhang F, Deng L#. (2019). The genetic alteration spectrum of the SWI/SNF complex: The oncogenic roles of BRD9 and ACTL6A. PLoS One. 14(9): e0222305.

13.Cheng Z, Wen Y, Liang B, Chen S, Liu Y, Wang Z, Cheng J, Tang X, Xin H, Deng L#. (2019). Gene expression profile-based drug screen identifies SAHA as a novel treatment for NAFLD. Molecular Omics, 15(1): 50~58.

14.Shi C, Xu H, Liu J, Zhong Y, Zhang X, Tong X, Zhang L, Li X, Deng L#. (2019). Alternatively activated NUSAP1 promotes tumor growth and indicates poor prognosis in hepatocellular carcinoma. Transl Cancer Res, 8(1): 238~247.

15.Deng L, Huo L, Zhang J, Tang X, Cheng Z, Li G, Fang X, Xu J, Zhang X, Xu R. (2017). Polymorphism of rs3737597 in DISC1 Gene on Chromosome 1q42.2 in sALS Patients: a Chinese Han Population. Mol Neurobiol, 54(5):3162~3180.

16.Deng L, Zhang C, Miao D, Tang X, Luo S, Xin HB, Shi H. (2017). Mediator complex components are frequent targets for genetic alteration in various types of human cancer. J. Genet. Genomics, 44(12):587-591.

17.Hu Y, Deng L, Zhang J*, Fang X, Mei P, Cao X, Lin J, Wei Y, Zhang X, Xu R. (2016). A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson's Disease in the Han Population of Chinese Mainland. Mol Neurobiol, 53(7):4302-18.

18.Tang X, Deng L, Xiong H, Li G, Lin J, Liu S, Xie J, Liu J, Kong F, Tu G, Peng H, Liang S*. (2014). Expression Profiles of Skeletal Muscle and Liver Implicate MAPK Signaling Pathways in Diabetes Pathology. INDIAN J MED RES, 140(6):744-755.

19.Xie T, Deng L, Mei P, Zhou Y, Wang B, Zhang J, Lin J, Wei Y, Zhang X, Xu R. (2014). A genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. Neurobiol Aging, 35(7):1778.e9-1778.e23.

20.Tang X, Deng L, Zhang D, Lin J, Wei Y, Zhou Q, Li X, Li G, Liang S. (2012). Gene2DGE: a Perl package for gene model renewal with digital gene expression data. Genomics Proteomics Bioinformatics, 10(1):51-4.

21.Gao Y, Liu H, Deng L, Zhu G, Xu C, Li G, Liu S, Xie J, Liu J, Kong F, Wu R, Li G, Liang S. (2011). Effect of emodin on neuropathic pain transmission mediated by P2X(2/3) receptor of primary sensory neurons. Brain Res Bull, 84(6):406-13.

22.Deng L, Tang X, Hao X, Chen W, Yu Y, Zhang D, Zeng C. (2011). Genetic Flux Between H1 and H2 Haplotypes of the 17q21.31 Inversion in European Population. Genomics. Proteomics & Bioinformatics, 9(3): 113-118.

23.Deng L, Tang X, Chen W, Lin J, Lai Z, Liu Z, Zhang D. (2010). Scanning for Genomic Regions Subject to Selective Sweeps Using SNP-MaP Strategy. Genomics Proteomics Bioinformatics, 8(4): 256-261.

24.Deng L, Zhang D, Richards E, Tang X, Long F, Fang J, Wang Y. (2009) Constructing an initial map of transmission distortion based on high density HapMap SNPs across the human autosomes. J. Genet. Genomics, 36(12): 703-709.

25.Deng L, Zhang Y, Kang J, Liu T, Zhao H, Gao Y, Li C, Pan H, Tang X, Wang D, Niu T, Yang H, Zeng C. (2008). An Unusual Haplotype Structure on Human Chromosome 8p23 Derived from the Inversion Polymorphism. Hum Mutat, 29(10): 1209-1216.

26.Deng L, Tang X, Kang J, Wang Q and Zeng C. (2007). Scanning for signatures of geographically restricted selection based on population genomics analysis. Chinese Sci. Bull, 52(19): 2649-2656.

27.Luo C, Deng L, and Zeng C. (2004). High throughput SNP genotyping with two mini-sequencing assays. Acta Biochim.Biophys. Sin, 36: 379-384.

28.Luo C, Deng L, Zhou J, Lin W and Zeng C. (2004). High throughput SNP genotyping with FP-TDI. Prog. Biochem.Biophys, 31(8): 731-735.

(II) Patents and Software Copyrights:

1.A Molecular Subtyping Prediction System for Ovarian Cancer. Deng Libin, Wang Haoqing, Liang Bowen, Wang Zixuan, Yang Ailin, Fu Fen, Tang Xiaoli. China, ZL 2018 1 1389851.4. 2021/9/24 (Invention Patent)

2.An Intelligent Detection Method and System for Periodontitis Based on Convolutional Neural Network. Deng Libin, Song Li, Ge Shanghua, Liu Qiangdong, Dai Fang, Lou Weiming, Li Can, Yang Jingjing, Chen Linjia, Peng Jie, Tian Ju, Wu Jingting, Zou Yuan, Yu Qing. China, ZL 2020 1 0966941.6. 2022/8/30 (Invention Patent)

3.Periodontitis Staging and Grading System V1.0 Based on CNN. Deng Libin; Song Li; Dai Fang; Ge Shanghua; The Second Affiliated Hospital of Nanchang University. 2021SR0915429. 2021/6/18 (Software Copyright)

4.An Intelligent Method and System for Parkinson's Disease Prediction Based on Electrocardiogram Images. Deng Libin, Fan Guangqin, Feng Chang, Wang Yuting, Lou Weiming, Zhang Yichu, Xie Ruixiang, Huang Wei. CN202111580521.5. 2021/12/22 (Invention Patent)

5.A Prediction Method and System for Chemosensitivity of Ovarian Cancer Patients Based on Pathological Images. Deng Libin, Lou Weiming, Tang Xiaoli, Liu Yue, Ge Shanghua, Wu Yiguo, Gao Jianying, Fu Fen, Shi Chao. CN202111487778.6. 2021/12/7 (Invention Patent)

VII. Representative Research Projects

·2021.1-2024.12: National Natural Science Foundation of China, Regional Program, "Mechanism of PTMA in Promoting NAFLD by Altering Histone Modifications in Hepatocytes" (82060112)

·2017.1-2020.12: National Natural Science Foundation of China, Regional Program, "Omics Screening of PPARA-related rSNPs and Their Synergistic Pathogenic Mechanism in Hypercholesterolemia" (81660041)

·2013.1-2016.12: National Natural Science Foundation of China, Regional Program, "Omics Screening of Functional Mutations Associated with Familial Hypercholesterolemia and Establishment of Gene Knockout Mouse Models" (81260021)

·2009.1-2011.12: National Natural Science Foundation of China, General Program, "Study on the Role of Positive Selection in Population Differentiation and the Formation of Specific Genetic Background in Chinese" (30871384)

·2018.01-2020.12: Jiangxi Provincial Natural Science Foundation, General Program, "Mechanism of rSNPs in PPAR Signaling Pathway Disorder-Induced Hypercholesterolemia" (20181BAB205008)

·2012.01-2014.12: Jiangxi Provincial Natural Science Foundation, Youth Program, "Role of Liver Immune-Related Pathways in the Mechanism of High Glucose and High Fat Tolerance in Rats" (20114BAB215019)

·2013.01-2015.12: Jiangxi Provincial Department of Education, General Program, "Discovery and Functional Inference of Genetic Markers Associated with Physical Phenotype Characteristics in Han Chinese" (GJJ13091)

·2010.01-2011.12: Jiangxi Provincial Department of Education, General Program, "Survey of Candidate Gene Polymorphisms for Senile Dementia and Risk Prediction in Jiangxi Population" (GJJ10303)

·2017.11-2019.11: Jiangxi Postgraduate Education Innovation Program Project, "Exploration and Practice of Innovative Teaching of 'Bioinformatics' for Medical Postgraduates in the Context of Big Data" (JXYJG-2017-016)