杨必成

姓名：杨必成

职务\职称：副主任技师、科副主任

系别：医学检验

研究方向：出生缺陷防控

工作邮箱：yangbc1985@126.com

办公电话：0791-86206991

简介：现任江西省妇幼保健院江西省新生儿疾病筛查中心副主任，副主任技师，硕士生导师，中国科学院博士，主要从事质谱技术在出生缺陷防控创新与应用研究，2019年入选江西省“双千计划”首批培养类科技创新高端人才，2018年入选江西省百千万人才，为国家自然科学基金和省科技计划项目评审专家，任中国优生优育协会理事等，以第1完成人获全国妇幼健康科学技术奖1项，获批主持国家自然科学基金项目3项，获批主持省部级课题4项，已发表学术论文51篇，其中SCI收录论文31篇，获中国发明专利9项，编写专著2部。

论文、专著与专利：

1.Bi-cheng Yang#, Xi-di Wan#, Xiao Yang, Yun-jun Li, Zi-yu Zhang, Xiao-ju Wan, Yong Luo, Wei Deng, Feng Wang*, Ou-ping Huang*, Rapid determination of carbendazim in complex matrices by electrospray ionization mass spectrometry with syringe filter needle, Journal of Mass Spectrometry, 2018, 53(3): 234-239.

2.Bi-cheng Yang, Liqun Wang, Xiaoju Wan, Yunjun Li, Xiaohong Yu, Yunna Qin, Yong Luo, Feng Wang, Ouping Huang*, Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis, BMC Women's Health, 2017, 17: 118-125.

3.Bi-cheng Yang, Feng Wang*. Two Novel Missense Mutations in Very Long Chain Acyl-CoADehydrogenase Deficiency. Indian Pediatrics, 2018, 55,1-3.

4.Bi-cheng Yang, Wenyan Tang*. Novel Heterozygous PCCA Mutations with Fatal Outcome in Propionic Acidemia. Indian Pediatrics, 2018;55(6):529-530.

5.Bi-cheng Yang, Feng Wang*. Two Novel Heterozygous MCCC1 Mutations in a Neonate with Asymptomatic 3-methylcrotonyl-coenzyme A Carboxylase Deficiency. Indian Pediatrics, 2018. 55(6):528-529.

6.Bi-cheng Yang, Shu-fen Fang, Xiao-ju Wan, Yongi Luo, Jiang-Yan Zhou, You Li, Yun-jun Li, Feng Wang*, Ou-ping Huang*. Quantification of monohydroxylated polycyclic arodrocarbons in human urine samples using solid-phase microextraction coupled with glass-capillary nanoelectrospray ionization mass spectrometry. Analytica Chimica Acta, 2017,973,22,68-74.

7.Bi-cheng Yang#, Wang Feng#, Xiao Yang, Wei Zou, Jia-chun Wang, Yang Zou, Fa-ying Liu, Huai Liu*, Ou-ping Huang*. Medical swab touch spray-mass spectrometry for newborn screening of nicotine and cotinine in meconiumy. Journal of Mass Spectrometry. 2016, 51（12）:1237-1242.

8.Bi-cheng Yang#, Fa-ying Liu#, Li-qun Wang, Yang Zou, Feng Wang, Wei Deng, Xi-di Wan, Xiao Yang, Ming He*, Ou-ping Huang*. Serum metabolic profiling study of endometriosis by using wooden-tip electrospray ionization mass spectrometry. Analytical Methods (2015),7,6125-6132.

9.Bi-Cheng Yang#, Feng Wang#, Wei Deng, Yang Zou, Fa-ying Liu, Xi-di Wan, Xiao Yang, Huai Liu*, Ou-ping Huang*. Wooden-tip Electrospray Ionization Mass Spectrometry for trace analysis of toxic and hazardous compounds in Food Samples. Analytical Methods (2015),7,5886-5890.

10.Bi-cheng Yang#, Fa-ying Liu#, Jiu-bai Guo, Lei Wan, Juan Wu, Feng Wang, Huai Liu*, Ou-ping Huang*. Rapid assay of neopterin and biopterin in urine by wooden-tip electrospray ionization mass spectrometry. Analytical Methods (2015),7,2193-2196. (Cover paper).

11.Bi-cheng Yang, Li-li Jin, Yi-fang Yang*, Kun Li, Dan-ming Pan. Inhibitory effect of rape pollen supercritical CO2 fluid extract against testosterone-induced benign prostatic hyperplasia in rats. Experimental and Therapeutic Medicine. 2014, 8, 31-37.

12.Bi-cheng Yang, Zhi-hua Yang, Xiu-jie Pan, Xing-yu Liu, Mao-xiang Zhu*, Jian-ping Xie*. Transcript profiling analysis of in vitro cultured macrophages after exposure to crotonaldehyde. The Journal of Toxicological Sciences. 2014, 39(3): 487-497.

13.Bi-cheng Yang, Zhi-hua Yang, Xiu-jie Pan, Feng-jun Xiao, Xing-yu Liu, Mao-xiang Zhu*, Jian-ping Xie*. Crotonaldehyde-exposed macrophages induce IL-8 release from airway epithelial cells through NF-κB and AP-1 pathways. Toxicology Letters. 2013, 219: 26-34.

14.Bi-cheng Yang, Zhi-hua Yang, Xiu-jie Pan, Xing-yu Liu, Mao-xiang Zhu*, Jian-ping Xie*. Crotonaldehyde induces apoptosis and   immunosuppression in alveolar macrophages. Toxicology in Vitro, 2013, 27(1): 128-137.

15.Bi-cheng Yang, Xiu-jie Pan, Zhi-hua Yang, Feng-jun Xiao, Xing-yu Liu, Mao-xiang Zhu*, Jian-ping Xie*. Crotonaldehyde induces apoptosis in alveolar macrophages through intracellular calcium, mitochondria and p53 signaling pathways. The Journal of Toxicological Sciences. 2013, 38(2): 225-235.

16.Xiao Yang, Huang Huang, Qing Lu, Shao-hong Chen,aFeng Wang, Ou-ping Huang, Bin Hu,* Bi-cheng Yang*, High-throughput Polymer Tip-Electrospray Ionization Mass Spectrometry for Enhanced Detection of Neopterin and Biopterin in Clinical Urine Samples,  Journal of Mass Spectrometry, 2019,54（2）：189-194.

17.Huang Huang, Qicai Wu, Liang Zeng, Li Wan, SongQing Lai, Xiujie Ying, Jianfeng Huang, Bicheng Yang*, Jichun Liu*. Heating paper spray mass spectrometry for enhanced detection of propranolol in dried blood samples.

18.Guozhu Ye, Han Gao, Qiansheng Huang, Yi Lin, Xu Liao, Han Zhang & BichengYang*, Metabolomic Characterization of Metabolic Disturbances in the Extracellular Microenvironment of Oleate-Treated Macrophages Using Gas Chromatography–MassSpectrometry, Alalytical Letters, 2020,53(16),2619-2635.

19.邹阳，张子宇，黄欧平，刘淮，王枫，杨必成，一种快速检测新生儿胎粪中尼古丁和可替宁含量的方法， 一种从蜂花粉中提取脂肪类化合物的方法，2018.11，中国发明专利，105548335B

主持的科研项目：

1、国家自然科学基金项目：基于木签电喷雾电离质谱的尿喋呤检测新方法及其在新生儿苯丙酮尿症和四氢生物喋呤缺乏症早期鉴别诊断中的应用，NO: 81740164，主持人：杨必成，项目起止年月：2018.1-2018.12，20万元，已结题。

2、国家自然科学基金项目：基于代谢组学的子宫内膜异位症发病机制和诊断生物标志物研究，NO: 81460232，主持人：杨必成，起止年月：2015.1-2018.12，48万元，已结题。

3、国家自然科学基金项目：傣药麻欠精油抑制子宫内膜异位种植的作用及机制研究，NO: 81860888，主持人：杨必成，项目起止年月：2019.1-2022.12，36万元。

4、江西省“双千计划”科技创新高端人才项目：主持人：杨必成，项目起止年月：2020.1-2022.12，100万元。